Brand and Other Names:Betagan, AKBeta
- Classes: Antiglaucoma, Beta-Blockers
Dosing & Uses
Dosage Forms & Strengths
0.25%: 1-2 gtt in affected eye(s) q12hr
0.5%: 1-2 gtt in affected eye(s) qDay, may increase to q12hr; >1 gtt q12hr generally not more effective; consider concomitant therapy if IOP not at satisfactory level on this regimen
Safety & efficacy not established
Frequency Not Defined
Mild ocular stinging
Decreased visual acuity
Decreased corneal sensitivity
Decreased blood pressure
Reduction of resting heart rate
Asthma, uncompensated CHF, any beta-blocker side effects, COPD, sinus bradycardia, 2°/3° AV block, hypersensitivity
Cardiogenic shock or with overt cardiac failure not adequately compensated (eg, treated with cardiac glycosides &/or diuretics)
Caution on inadequate cardiac function, latent cardiac insufficiency, cerebrovascular insufficiency, sick sinus syndrome, peripheral vascular disease, history of psychiatric illness, heart failure, diminished pulmonary function, nonallergic bronchospasm, diabetes mellitus, myasthenia gravis
Patients receiving topical levobunolol & a systemic ß-adrenergic blocking agent concomitantly should be observed carefully for potential additive effects on IOP &/or systemic effects of ß-adrenergic blockade
May mask signs of hyperthyroidism (ie, tachycardia)
Remove contact lens prior to administration
Use with a miotic in angle-closure glaucoma
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Not known if distributed into milk, use caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Nonselective beta-adrenergic receptor blocker; reduces IOP by reducing production of aqueous humor
Peak Plasma Time: 30 min
Onset of action: 1hr
Peak effect: 2-6hr
Duration: Up to 24hr
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