betaxolol (Rx)

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Brand and Other Names:Kerlone

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 10mg
  • 20mg
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Hypertension

5-20 mg PO qDay

Renal Impairment

Severe impairment: 5 mg PO qDay; may increase every 2 weeks to maximum 20 mg/day

Other Information

Less effective than thiazide diuretics in black and geriatric patients

Shown to decrease mortality in hypertension and post-myocardial infarction

Hypertension

Safety and efficacy not established

Hypertension: 5 mg PO qDay

Consideration should be given to reducing the starting dose to 5 mg in elderly patients

Elderly are especially prone to beta-blocker–induced bradycardia, which appears to be dose related and sometimes responds to reductions in dose

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Interactions

Interaction Checker

and betaxolol

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            2-10%

            Fatigue (2-10%)

            Bradycardia (6-8%)

            Chest pain (2-7%)

            Dyspepsia (2-5%)

            Lethargy (3%)

            Cold extremeties (2%)

            Diarrhea (2%)

            Dyspnea (2%)

            Edema (2%)

            Palpitation (2%)

            Pharyngitis (2%)

            <2% (selected)

            Angina

            Arrhythmia

            Flushing

            Depression

            Fever

            Hallucinations

            Malaise

            Neuropathy

            Rash

            Diabetes

            Hyperglycemia

            Anemia

            Hypercholesterolemia

            Hyperlipidemia

            Leukocytosis

            cataracts

            Constipation

            Dysphagia

            Libido decreased

            Proteinuria

            Bronchospams

            Cough

            Frequency Not Defined

            Decreased exercise tolerance, Raynaud's phenomenon

            May increase triglyceride levels and insulin resistance, and decrease HDL levels

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            Warnings

            Contraindications

            Sinus bradycardia, 2°/3° heart block, cardiogenic shock, overt cardiac failure, hypersensitivity, sick sinus syndrome without permanent pacemaker

            Cautions

            Bronchospastic disease, cerebrovascular insufficiency, CHF, cardiomegaly, DM, hyperthyroidism/thyrotoxicosis, liver disease, renal impairment, peripheral vascular disease (potential risk of reduced placental perfusion, fetal bradycardia, hypoglycemia), use in pheochromocytoma, IDDM

            Surgery/Anesthesia: Chronically administered beta-blockers should not be routinely withdrawn prior to major surgery; however, impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excreted in milk; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Beta adrenergic receptor blocker; cardioselective for Beta-1 receptor at low doses

            Pharmacokinetics

            Half-Life: 14-22 hr

            Bioavailability: 89%

            Protein Bound: 50%

            Excretion: Urine

            Onset of action: 1-1.5hr

            Peak Plasma

            • Time: 3 hr
            • Concentration: 21.6 ng/mL
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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
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            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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