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phendimetrazine (Rx)Brand and Other Names:Bontril PDM

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsules, extended release: Schedule III

  • 105mg

tablet: Schedule III

  • 35mg
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Obesity

Tablet: 35 mg q8-12hr 1 hr AC

Range: 17.5 mg q12hr to 70 mg q8hr; not to exceed 70 mg PO q8hr

Extended release capsule: 105 mg qAM

Because pediatric obesity is a chronic condition requiring long-term treatment, the use of amphetamines approved for short-term therapy is not recommended in patients <17 years of age

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Interactions

Interaction Checker

phendimetrazine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abnormal heart valve findings

            Agitation

            Blurred vision

            Changes in libido

            Constipation

            Diarrhea

            Dizziness

            Dryness of the mouth

            Dysphoria

            Dysuria

            Euphoria

            Flushing

            Headache

            Impotence

            Increased BP

            Insomnia

            Nausea

            Palpitation

            Primary pulmonary HTN

            Stomach pain

            Sweating

            Tachycardia

            Tremor

            Unpleasant taste

            Urticaria

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            Warnings

            Contraindications

            Hypersensitivity

            History of cardiovascular disease (eg, coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension, pulmonary hypertension)

            Hyperthyroidism

            Glaucoma

            Agitated states

            History of drug abuse

            Pregnancy

            Breast feeding

            Coadministration with other anorectic agents or CNS stimulants

            Do not administer within 14 days of administration of MAO inhibitors

            Cautions

            Impairs ability to drive or operate heavy machinery

            Primary pulmonary hypertension associated with treatment

            Use with other anorectic agents

            Possibility of addiction

            Caution advised; increased exposure expected when administered to patients with renal impairment; excreted in urine

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            Pregnancy & Lactation

            Pregnancy Category: X; weight loss offers no potential benefit to a pregnant woman and may result in fetal harm; a minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese

            Lactation: Contraindicated; do not nurse if taking this drug

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Anorectic; sympathomimetic amine similar to amphetmine; may act in CNS to reduce appetite

            Pharmacokinetics

            Metabolism: Forms 2 metabolites

            Metabolites: Phendimetrazine-N-oxide

            Absorption: readily absorbed from GI tract

            Duration: 4 hr

            Excretion: Urine

            Half-life: 1.9 hr (tablet); 9.8 hr (slow release)

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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