Seed extract: 200-1600 mg PO qDay; no more than 3 g/day
Standardized dry extract: 150 mg PO qDay
200-800 mg before breakfast or lunch PO qDay, no more than 3 g/day
486 mg PO qD
Diarrhea or Dysentery
1 g PO no more than QID
Weight loss, to enhance athletic performance, to reduce mental and physical fatigue, hypotension, chronic fatigue syndrome (CFS), stimulant, diuretic, and astringent, prevent malaria and dysentery
May cause weight loss when taken in combination with mate and damiana. More evidence is needed to rate effectiveness
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Abdominal spasms (from overdose)
Painful urination (from overdose)
Duodenal ulcer, gastric ulcer
Anxiety disorders, arrhythmias, cardiac disease, depression, hypertension, kidney disease
Pregnancy & Lactation
Pregnancy Category: N/A
Lactation: avoid use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Contains 2.5-5% caffeine; see caffeine