brompheniramine/phenylephrine (Rx)

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Brand and Other Names:Brovex PB, Respahist-II, more...Vazotab Chewable, Children's Dimetapp Cold & Allergy

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

brompheniramine/phenylephrine

tablet, chewable

  • 6mg/15mg

oral suspension

  • (6mg/10mg)/5mL
  • (1.2mg/2mg)/1mL

oral liquid

  • (1mg/2.5mg)/5mL
  • (2mg/5mg)/5mL

elixir

  • (1mg/2.5mg)/5mL
more...

Congestion

brompheniramine/phenylephrine

3 mL [(1.2 mg/2 mg)/1 mL] PO q4-6hr; not to exceed 18 mL/24hr

5 mL [(4 mg/10 mg)/5 mL] PO q4-6hr; not to exceed 30 mL/24hr

20 mL [(1mg/2.5mg)/5mL] PO q4-6hr; not to exceed 120 mL/24hr

Administration

Refer to manufacturer information for dosing details; multiple strengths available

Administer liquids with special measuring device for accurate dose

Dosage Forms & Strengths

brompheniramine/phenylephrine

tablet, chewable

  • 1mg/2.5mg
  • 6mg/15mg

oral suspension

  • (6mg/10mg)/5mL
  • (1.2mg/2mg)/1mL

oral liquid

  • (1mg/2.5mg)/5mL
  • (2mg/5mg)/5mL

elixir

  • (1mg/2.5mg)/5mL
more...

Congestion

brompheniramine/phenylephrine

Refer to manufacturer information for dosing details; multiple strengths available

2-6 years: 5 mL [(1mg/2.5mg)/5mL] PO q4hr; not to exceed 30 mL/24hr

6-12 years: 10 mL [(1mg/2.5mg)/5mL] PO q4-6hr; not to exceed 60 mL/24hr

Alternatively, 1.5 mL [(1.2 mg/2 mg)/1 mL] PO q4-6hr; not to exceed 9 mL/24hr

>12 years: 3 mL [(1.2 mg/2 mg)/1 mL] PO q4-6hr; not to exceed 18 mL/24hr

Alternatively, 5 mL [(4 mg/10 mg)/5 mL] PO q4-6hr; not to exceed 30 mL/24hr

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Adverse Effects

Phenylephrine (Common)

Hypertension, reflex bradycardia

Anxiety, dizziness, excitability, headache, nervousness, restlessness

Rebound congestion, sneezing, pulmonary edema

Brompheniramine (Common)

Anticholinergic effects (blurred vision, dry mouth/nose, throat)

Drowsiness, dizziness, decreased  coordination, headache

Constipation, stomach upset

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Warnings

Contraindications

Hypersensitivity to brompheniramine or phenylephrine

Use within 14 days of MAO therapy

Sedation of children

Breast feeding of newborn

Severe CAD or hypertension

Acute asthma attack

Urinary retention

Peptic ulcer

Cautions

May impair mental abilities (CNS depression)

Caution on CAD, diabetes mellitus, BPH, pyloroduodenal obstruction, respiratory disease, thyroid dysfunction

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Pregnancy & Lactation

Pregnancy category: C; not recommended in first tri-mester or last 2 weeks of pregnancy

Lactation: Contraindicated

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Brompheniramine: Histamine H1-receptor antagonist; elicits high antihistamine activity, low sedative effects, and moderate anticholinergic effects

Phenylephrine: A vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia; also has strong alpha effects resulting in increased PVR and BP and decreased CO and renal perfusion;

Absorption

Onset: 15-30 min

Duration: 3-9 hr, may last 48 hr (brompheniramine); 2-4 hr (phenylephrine)

Peak Plasma Time: 2-5 hr (brompheniramine)

Distribution

Vd: 11.7 L/kg (brompheniramine)

Metabolism

Brompheniramine: Mainly liver; metabolites include propionic acid derivative conjugated with glycine

Phenylephrine: Liver and intestine by MAO

Elimination

Half-Life: 11.8-34.7 hr (brompheniramine)

Excretion: Urine

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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