0.2-2 g/day whole herb PO
Commerically available preparation: 2 tablet (40 mg) PO qD
Hyperthyroidism, PMS, breast pain, nervousness, insomnia; and bleeding, especially nosebleeds and heavy bleeding during menses
There is insufficient reliable information available about the effectiveness
Serious - Use Alternative
Significant - Monitor Closely
None in regular doses
May cause hypoglycemia
Pregnancy & Lactation
Pregnancy Category: avoid
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Contains organic acids, eg, lithospermic acid that decrease levels of several hormones, particularly TSH & thyroxine (T4)
Also inhibits binding of antibodies to thyroid that cause Graves disease