buspirone (Rx)

Brand and Other Names:BuSpar, Buspirex, more...Bustab, LinBuspirone
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 5mg
  • 7.5mg
  • 10mg
  • 15mg
  • 30mg
more...

Anxiety Disorders

10-15 mg/day PO divided q8-12hr; may increase every 2-3 days by 5 mg/day to 15-30 mg/day PO divided q8-12hr; not to exceed 60 mg/day

Smoking Cessation (Off-label)

30-60 mg/day PO for 9-13 weeks; begin 2-3 weeks before quit date

Dosing Modifications

Renal impairment: Not recommended for patients with severe impairment

Hepatic impairment: Not recommended for patients with severe impairment

Dosage Forms & Strengths

tablet

  • 5mg
  • 7.5mg
  • 10mg
  • 15mg
  • 30mg
more...

Generalized Anxiety Disorder (Off-label)

Pre-adolescent: 2.5-5 mg PO qDay; may increase dose by 2.5 mg every 3-4 days; not to exceed 20 mg/day

Adolescent: 5-10 mg PO qDay; may increase by 5 mg/day at weekly intervals PRN; not to exceed 60 mg/day divided q8-12hr

Dosing Modifications

Renal impairment: Not recommended for patients with severe impairment

Hepatic impairment: Not recommended for patients with severe impairment

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Interactions

Interaction Checker

and buspirone

No Results

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Dizziness (12%)

            1-10%

            Drowsiness (10%)

            Nausea (8%)

            Headache (6%)

            Nervousness (5%)

            Blurred vision (2%)

            Confusion (2%)

            Diarrhea (2%)

            Excitement (2%)

            Insomnia (2%)

            Myalgia (1%)

            Numbness (2%)

            Paresthesia (1%)

            Rash (1%)

            Tremor (1%)

            Weakness (2%)

            Nasal congestion (1%)

            Sore throat (1%)

            Nonspecific chest pain (1%)

            Tinnitus (1%)

            Dream disturbances (1%)

            <1%

            Akathisia

            Allergic reaction

            Anorexia

            Bruising

            Galactorrhea

            Heart failure

            Menstrual irregularity

            Suicidal ideation

            Syncope

            Alopecia

            Eosinophilia

            Edema

            Enuresis

            Increased ocular pressure

            Visual disturbances

            Rectal bleeding

            Photophobia

            Dystonia

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Do not use PRN for anxiety

            Will not prevent withdrawal from other anxiolytics, such as benzodiazepine

            May cause cognitive motor impairment

            Restlessness syndrome associated with therapy

            Use in severe renal/hepatic impairment not recommended

            Use with MAO inhibitors may result in hypertensive reaction (use not recommended)

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            Pregnancy & Lactation

            Pregnancy category: B

            Lactation: Excretion in milk unknown/not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Is an azaspirodecanedione; high affinity for serotonin 5HT1A and 5HT2 receptors and moderate affinity for dopamine D2 receptors, but no effect on benzodiazepine GABA receptors

            No anticonvulsant, muscle relaxant, or sedative effects

            Absorption

            Bioavailability: ~4%

            Onset: 2-4 wk (anxiolytic effects)

            Peak serum time: 40-90 min

            Peak plasma concentration: 1-6 ng/mL

            Distribution

            Protein bound: 86%

            Vd: 5.3 L/kg

            Metabolism

            Hepatic metabolism by CYP3A4

            Metabolites: 1-pyrimidinylpiperazine (1-PP)

            Elimination

            Half-life: 2-3 hr

            Excretion: Urine (29-63%); feces (18-38%)

            Total body clearance: 28 mL/min/kg

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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