butabarbital (Rx)Brand and Other Names:Butisol

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

elixir: Schedule III

  • 30mg/5mL

tablet: Schedule III

  • 30mg
  • 50mg
more...

Sedative or Hypnotic

Hypnotic: 50-100 mg qHS

Daytime sedation: 15-30 mg q6-8hr

Preoperative sedation: 50-100 mg 60-90 minutes before surgery

Renal Impairment

Reduce dosage if use is necessary

Hepatic Impairment

Reduce dosage if use is necessary

Dosage Forms & Strengths

elixir: Schedule III

  • 30mg/5mL

tablet: Schedule III

  • 30mg
  • 50mg
more...

Sedation

Preoperative sedation: 2-6 mg/kg; not to exceed 100 mg/dose 

Use with caution; may administer a dose at the low end of the range

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Interactions

Interaction Checker

butabarbital and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Somnolence

            <1%

            Abnormal thinking

            Agitation

            Anxiety

            Apnea

            Ataxia

            Bradycardia

            CNS depression

            Confusion

            Constipation

            Dizziness

            Fever

            Hallucination

            Headache

            Hepatotoxicity

            Hypersensitivity rxn

            Hypoventilation

            Insomnia

            Nausea

            Nervousness

            Nightmares

            Psychiatric disturbance

            Vomiting

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            Warnings

            Contraindications

            Barbiturate or tartrazine sensitivity, liver disease, severe respiratory disease, porphyria

            Cautions

            May impair mental and physical abilities by depressing the central nervous system

            May cause hyperactivity and agitation

            Use caution in patients with depression, renal or hepatic impairment, or respiratory disease

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            Pregnancy & Lactation

            Pregnancy Category: D

            Lactation: Enters breast milk; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Interferes with transmission of impulses from the thalamus to the cortex; depresses sensory cortex & decreases motor activity

            Pharmacokinetics

            Half-Life: ~100 hr

            Duration: 6-8 hr

            Onset: 45-60 min

            Enzymes induced: CYP1A2, CYP2C9/10, CYP3A4

            Excretion: Urine

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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