caffeine (Rx, OTC)

Brand and Other Names:Cafcit, NoDoz, more...ReCharge, Vivarin
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 20mg/mL

oral solution

  • 20mg/mL

tablets

  • 200mg

capsules

  • 200mg

lozenges

  • 75mg
more...

Fatigue & Drowsiness

100-200 mg PO q3-4hr; not later than 6 hours before bedtime

Respiratory Failure

Caffeine and sodium benzoate: 250 mg IV/IM once; may repeat PRN; alternatively, 500 mg in 1 L IV over 4 hr; not to exceed 2500 mg/24hr

CAUTION: Use strongly discouraged

Stimulant Diuretic (Off-label)

500 mg IV/IM; 1 g maximum single dose

Dosage Forms & Strengths

injectable solution

  • 10mg/mL

oral solution

  • 10mg/mL

tablets

  • 200mg

capsules

  • 200mg

lozenges

  • 75mg
more...

Drowsiness or Fatigue

< 12 years: Not recommended

>12 years: 100-200 mg PO q3-4hr; not later than 6 hours before bedtime

Potential toxic dose <6 years old: 15 mg/kg

Neonatal Apnea

Load: 10-20 mg/kg IV/PO once 

Maintenance: 5-10 mg/kg IV/PO qDay

Potential toxic dose <6 years old: 15 mg/kg

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Interactions

Interaction Checker

and caffeine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Tachycardia

            Palpitations (dose dependent)

            Insomnia

            Irritability

            Nervousness

            Restlessness

            Tremor

            Tinnitus

            Regular and decaffeinated coffee increase gastric acid & pepsin secretion

            Nausea

            Vominting

            Diarrhea

            Diuresis

            Withdrawal symptoms

            • Anxiety
            • depression
            • Fatigue
            • Headache (can last up to 7 days)
            • Muscle tension
            • Nausea
            • Runny nose
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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            May increase severity of fibrocystic breast disease, PMS, increase risk of bladder, ovary, colon & pancreatic cancer

            Not for use in patients with anxiety, agitation, or tremor

            Caution in patients with history of peptic ulcer, hepatic impairment, renal impairment, seizure disorder, or cardiovascular disease

            Avoid use in symptomatic arrhythmias and/or palpitations

            See Caffeine OD for caffeine content of specific foods & drinks

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            Pregnancy & Lactation

            Pregnancy Category: C (crosses placenta, can remain in fetus/neonate 64-300 hr)

            Lactation: enters breast milk; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Methylxanthine; promotes cAMP accumulation by inhibiting phosphodiesterase; increases medullary respiratory center sensitivity to carbon dioxide; may prevent apnea by acting as an adenosine receptor antagonist

            Pharmacokinetics

            Half-Life: 72-96hr (neonates); 5 hr (>9 months and adults); decreased in tobacco user

            Peak plasma time:  30-120 min

            Peak plasma concentration: 1.5-1.8 mcg/mL

            Protein Bound: 17-36%

            Vd: 0.6-0.9 L/kg

            Metabolism: hepatic CYP1A2

            Excretion: Urine

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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