calcium carbonate/vitamin D3 (OTC)Brand and Other Names:Caltrate 600+D3, Os-Cal Calcium + D3, more...Os-Cal Extra D3, Os-Cal Ultra

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

calcium carbonate/vitamin D&sub3;

tablet

  • 500mg/200 IU (Os-Cal Calcium + D&sub3;)
  • 500mg/600 IU (Os-Cal Extra D&sub3;)
  • 600mg/500 IU (Os-Cal Ultra)
  • 600mg/800 IU (Caltrate + D&sub3;)
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Calcium Supplementation

NIH recommended daily intake

  • Elemental calcium and vitamin D
  • 19-50 years: 1000 mg/200 IU daily
  • ≥51-70 years (females): 1200 mg/400 IU
  • ≥51 years (males): 1000 mg/400 IU
  • ≥70 years (females): 1200 mg/600 IU
  • Osteoporosis prevention in adults ≥50 years: Vitamin D intake may need to be increased to 800-1000 mg/day

Dosing Considerations

Calcium carbonate (elemental calcium equivalent)

  • 500 mg (200 mg)
  • 600 mg (240 mg)

High risk for vitamin D deficiency

  • Age ≥50 yr
  • African Americans and others with dark pigmented skin
  • Individuals with limited sun exposure
  • Individuals who consistently wearing sunscreen SPF ≥8

Administration

Tablet strengths are varied; check content of calcium and vitamin D carefully to assure dosage

Take with food

Dosage Forms & Strengths

calcium carbonate/vitamin D&sub3;

tablet

  • 500mg/200 IU (Os-Cal Calcium + D&sub3;)
more...

Calcium Supplementation

NIH recommended daily intake

  • Elemental calcium and vitamin D
  • Adolescents (9-18 years): 1300 mg/200 IU

Dosing Considerations

Calcium carbonate (elemental calcium equivalent)

  • 500 mg (200 mg)
  • 600 mg (240 mg)

Administration

Tablet strengths are varied; check content of calcium and vitamin D carefully to assure dosage

Take with food

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Interactions

Interaction Checker

calcium carbonate/vitamin D3 and

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Calcium carbonate

            • Anorexia
            • Constipation
            • Flatulence
            • Nausea
            • Vomiting
            • Hypercalcemia
            • Hypophosphatemia
            • Xerostomia
            • Acid rebound
            • Milk-alkali syndrome

            Vitamin D

            • Hypercalcemia
            • Muscle/bone pain
            • Metallic taste
            • Headache
            • Nausea
            • Vomiting
            • Dry mouth
            • Constipation
            • Arrhythmias
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            Warnings

            Contraindications

            Calcium carbonate

            • Hypersensitivity
            • Hypercalciuria
            • Renal calculi
            • Hypophosphatemia
            • Hypercalcemia
            • Suspected digoxin toxicity

            Vitamin D

            • Hypercalcemia
            • Hypervitaminosis D
            • Ergocalciferol (oral) GI, liver, or biliary disease associated with malabsorption of vitamin D analogs

            Cautions

            Calcium carbonate

            • Caution with history of kidney stones

            Vitamin D

            • Ergocalciferol: renal impairment (strong caution); heart disease, kidney stones, arteriosclerosis
            • Discontinue if patient becomes hypercalcemic
            • Concurrent cardiac glycosides
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            Pregnancy & Lactation

            Pregnancy Category: C (calcium carbonate)

            Lactation: Distributed in human breast milk

            Supplement calcium and vitamin D during pregnancy and lactation according to recommended daily allowance

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Prevents or treats negative Ca balance

            Absorption

            Bioavailability: 25-35% (calcium carbonate)

            Distribution

            Protein bound: 45% (calcium carbonate)

            Metabolism

            Vitamin D is metabolized in the liver

            Elimination

            Excretion (calcium carbonate): 80% as unabsorbed calcium in feces, 20% urinary via urine

            Excretion (vitamin D): Urine

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