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sucralfate (Rx)Brand and Other Names:Carafate

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 1g

oral suspension

  • 1000mg/10mL
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Duodenal Ulcer

1 g PO q6hr initially; maintenance: 1 g PO q12hr

Take on empty stomach 1 hour before or 2 hours after meals

Stress Ulcer (Off-label)

Prophylaxis

1 g PO q6hr for 4-8 weeks

Take on empty stomach 1 hour before or 2 hours after meals

Epidermolysis Bullosa (Orphan)

Treatment of oral ulcerations and dysphagia in patients with epidermolysis bullosa

Orphan indication sponsor

  • Darby Pharmaceuticals, Inc, 100 Banks Ave, Rockville Centre, NY 11570

Oral Complications After Bone Marrow Transplantation (Orphan)

Treatment of oral complications of chemotherapy in bone marrow transplant recipients

Orphan indication sponsor

  • Darby Pharmaceuticals, Inc, 100 Banks Ave, Rockville Centre, NY 11570

Dosing Modifications

Renal failure: Use with caution; aluminum salt may accumulate

Active Duodenal Ulcer (Off-label)

40-80 mg/kg/day PO divided q6hr

Stomatitis (Off-label)

500-1000 mg PO q6hr; 1g/10mL suspension q6hr; swish and spit or swish and swallow the suspension

Gastric Ulcer (Off-label)

40-80 mg/kg/day PO divided q6hr or 0.5-1 g PO q6hr

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Interactions

Interaction Checker

sucralfate and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Constipation (2%)

            <1%

            Diarrhea

            Dizziness

            Dry mouth

            Flatulence

            Headache

            Indigestion

            Insomnia

            Nausea

            Vertigo

            Vomiting

            Frequency Not Defined

            Bezoars formation

            Gastrointestinal discomfort

            Postmarketing Reports

            Hypersensitivity reactions

            Hyperglycemia

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            Warnings

            Contraindications

            Documented hypersensitivity

            Cautions

            Not expected to alter posthealing frequency of recurrence or severity of duodenal ulceration; acts locally at the ulcer

            Do not take antacids within 30 minutes of sucralfate dose

            Aluminum absorption is increased;, use with caution in patients with chronic renal failure or udnergoing dialysis

            Potential significant drug interactions possible; consult drug interaction database

            Use tablet with caution in patients with conditions that may impair swallowing, or with altered gag/cough reflex

            Hyperglycemia has been reported when drug is used in patients with diabetes

            Sucralfate may alter absorption of some drugs; take other medications 2 hours before taking sucralfate

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            Pregnancy & Lactation

            Pregnancy category: B

            Lactation: Probably safe because drug is minimally absorbed; unknown whether drug is excreted in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Forms ulcer-adherent complex; protects ulcer from acid, pepsin, and bile salts, thus allowing it to heal

            Absorption

            Bioavailability: 5% (sucralfate is considered nonsystemic); sucrose octasulfate, 5%; aluminum, 0.005%

            Onset: 1-2 hr

            Duration: Up to 6 hr

            Metabolism

            Not metabolized

            Elimination

            Dialyzable: Yes

            Excretion: Primarily urine (as unchanged drug)

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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