Infusion: 2 g/150 mL water PO qD
1 cup (1.5-3 g/150 mL water) PO TID
4-6 g/d div TID PO (recommended by the German Commission E monograph)
Tincture (1 g/5 mL): 10 mL PO qD
Fluidextract (1 g/mL): 2 mL PO qD OR 1.5-3 mL (1:1 in 25% alcohol) PO TID
Indigestion, diarrhea, heartburn, poor appetite, flatulent dyspepsia, bronchial catarrh
Topical use: injured skin, gangrenous & indolent ulcers
Viral infections; antimicrobial effects in laboratory studies
Induced abortion: unclear safe and effective dosage
Increase breast milk flow: not recommended-see cautions
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Vomiting (>5 g dose)
Allergy to blesssed thistle
Crohn's disease, inflammatory bowel conditions, irritable bowel syndrome, ulcer
Do not confuse with milk thistle or other thistle products
Using to increase breast milk flow is discouraged since effect on nursing infant unknown
<18 years: not recommended
Pregnancy & Lactation
Pregnancy Category: not recommended
Lactation: not recommended
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Active constituent: sesquiterpene lactones including cnicin
Stimulates secretion of saliva and gastric juices; antibacterial activity