urea/hydrocortisone topical (Rx)

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Brand and Other Names:Carmol HC, U-Cort

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

urea/hydrocortisone topical

topical cream

  • 10%/1%
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Dermatoses

Relief of inflammation and pruritic associated with corticosteroid-responsive dermatoses

Apply to affected area q6-12hr; discontinue therapy when control achieved

If no improvement within 2 weeks, reassess diagnosis

Dosing Forms & Strengths  

Urea/hydrocortisone topical

topical cream

  • 10%/1%

Dermatoses

Apply to affected area q6-12hr; discontinue therapy when control achieved

If no improvement within 2 weeks, reassess diagnosis

Limit use in children to least amount compatible with an effective therapeutic regimen    

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Interactions

Interaction Checker

and urea/hydrocortisone topical

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Burning

            Itching

            Irritation

            Dryness

            Folliculitis

            Hypertrichosis

            Acneiform eruptions

            Hypopigmentation

            Perioral dermatitis

            Allergic contact dermatitis

            Maceration of the skin

            Secondary infection

            Skin atrophy

            Striae

            Miliaria

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            Warnings

            Contraindications

            Hypersensitivity to any components of preparation

            Hepatic insufficiency

            Cautions

            Prolonged use may result in fungal or bacterial infection

            Contains sodium metabisulfite, which may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people

            Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria

            Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use and the addition of occlusive dressings Evaluate susceptible patients periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests; If HPA axis suppression is noted, withdraw the drug, reduce frequency of application, or substitute less potent steroid

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Systemic hydrocortisone is excreted in breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Hydrocortisone: anti-inflammatory, antipruritic and vasoconstrictive actions; mechanism of anti-inflammatory activity of topical corticosteroids unclear

            Absorption

            Extent determined by many factors including vehicle, integrity of epidermal barrier, use of occlusive dressings

            Protein Bound

            Variable

            Metabolism

            Primarily by liver

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            Formulary

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            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
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