Chondroitin Sulfate (Herbs/Suppl)

Brand and Other Names:CDS, condroitin, more...GAG, galactosaminoglucuronoglycan
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Suggested Dosing

Osteoarthritis

200-400 mg PO BID-TID, OR

1000-1200 mg PO qD

Also used in combo with glucosamine

MI, recurrent prophylaxis

Initial: 10 g PO div TID x 3 months THEN

Maintenance: 500 mg PO TID

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Suggested Uses

Osteoarthritis, hyperlipidemia, ischemic heart disease, osteoporosis

Efficacy

A compilation of the studies indicates patients with OA of the knee can experience some benefit from taking chondroitin; however, pain relief is likely to be modest or possibly insignificant.

MI: Some preliminary evidence indicates a possible lower risk of MI or recurrent risk of MI. More studies are needed

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Adverse Effects

Allergic reactions, alopecia, constipation, diarrhea, edema, (eyelid/lower limb), epigastric pain, extrasystoles, nausea

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Warnings

Contraindications

Anticoagulated (IM use), clotting disorders (IM use)

Cautions

Asthma

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Pregnancy & Lactation

Pregnancy Category: avoid use

Lactation: avoid use

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Cartilage derivative; component of hyaline cartilage matrix that may repair cartilage & reduce synovial inflammation

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