Celandine (Herbs/Suppl)

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Brand and Other Names:celandine poppy, chelidonium majus, more...greater celandine, tetterwort, Ukrain

Suggested Dosing

Average 2-5 g/day

Ukrain: 5-20 mg parenterally qD-q3d

Cancer: 50-300 mg IV qDay, with 100 mg IV qday most common

Available in Europe & Mexico & alternative/complementary health centers in the US

Dyspepsia

Oral: 1 mL TID

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Suggested Uses

Intestinal spasms, dyspepsia, liver disease, prevention of gallstone formation

Ukrain (celandine+thiotepa): cancers

Efficacy

Approved by German Commission E for intestinal spasms

Ukrain has selective cytotoicity against neoplastic cells in vitro; also some positive results but in small & possibly poorly-designed clinical studies

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Interactions

Interaction Checker

and Celandine

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Rashes, itching, serious allergic reactions

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            Warnings

            Contraindications

            Pregnancy, breastfeeding

            Cautions

            Potential risk of hepatitis

            Parts of the plant (esp roots) may be toxic

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            Pregnancy & Lactation

            Pregnancy Category: avoid

            Lactation: avoid

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Strong cholagogue

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