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ascorbic acid (Rx, OTC)Brand and Other Names:Cenolate, Vitamin C

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablets

  • 100mg
  • 250mg
  • 500mg
  • 1g

chewable, tablet

  • 100mg
  • 250mg
  • 500mg

capsule, extended release

  • 500mg

tablet, extended release

  • 500mg
  • 1000mg
  • 1500mg

crystals

  • 120g
  • 480g

granules

  • 100g
  • 500g
  • 1000g

injectable solution

  • 250mg/mL
  • 500mg/mL

oral solution

  • 100mg/mL

powder effervescent

  • 150g

powder, oral

  • 113mg
  • 120mg
  • 480mg

water, oral

  • 500mg

syrup, oral

  • 100mg/mL
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RDA

Males: 90 mg/day

Females: 75 mg/day

Pregnant: 85 mg/day; not to exceed 2000 mg/day (80 mg if <18 years; not to exceed 1800 mg/day)

Nursing: 120 mg/day; not to exceed 2000 mg/day (115 mg if <18 years old; not to exceed 1800 mg/day)

Urinary Acidification

4-12 g/day PO/IV divided three or four times daily

Macular Degeneration (Off-label)

500 mg/day PO with other vitamins and minerals

Ascorbic Acid Deficiency (Scurvy) (Orphan)

100 to 250 mg (0.2 to 0.5 mL ascorbic acid), PO/IV qDay/BID for at least 2 weeks

Extreme deficiency: 1-2 g (2 to 4 mL)

Orphan indication sponsor

  • McGuff Pharmaceuticals Inc; 2921 W. McArthur Blvd, Suite 141; Santa Ana, CA 92704-6929

Charcot-Marie-Tooth Disease (Orphan)

Designated orphan indication for Charcot-Marie-Tooth disease type 1A

Orphan designated sponsor

  • Murigenetics SAS; Faculte de Medecine Timone; 13005 Marseille, France

Dosage Forms & Strengths

tablets

  • 100mg
  • 250mg
  • 500mg
  • 1g

chewable, tablet

  • 100mg
  • 250mg
  • 500mg

capsule, extended release

  • 500mg

tablet, extended release

  • 500mg1000mg1500mg

crystals

  • 120g
  • 480g

granules

  • 100g
  • 500g
  • 1000g

injectable solution

  • 250mg/mL
  • 500mg/mL

oral solution

  • 100mg/mL

powder effervescent

  • 150g

powder, oral

  • 113mg
  • 120mg
  • 480mg

water, oral

  • 500mg

syrup, oral

  • 100mg/mL
more...

RDA

0-6 months: 40 mg/day

6-12 months: 50 mg/day

1-3 years: 15 mg/day

3-8 years: 25 mg/day

8-13 years: 45 mg/day

13-18 years: (male) 75 mg/day; (female) 65 mg/day

UL: 1-3 years: 400 mg/day; 4-8 years old: 600 mg/day; 9-13 years old: 1.2 g/day; 12-18 years old: 1.8 g/day

Urinary Acidification

500 mg/day divided PO/IV TID/QID

Ascorbic Acid Deficiency (Scurvy) (Orphan)

100-300 mg/day PO/IV/IM/SC divided BID

Orphan indication sponsor

  • McGuff Pharmaceuticals Inc; 2921 W. McArthur Blvd, Suite 141; Santa Ana, CA 92704-6929

Charcot-Marie-Tooth Disease (Orphan)

Designated orphan indication for Charcot-Marie-Tooth disease type 1A

Orphan designated sponsor

  • Murigenetics SAS; Faculte de Medecine Timone; 13005 Marseille, France
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Interactions

Interaction Checker

ascorbic acid and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Flushing

            Flank pain

            Faintness, headache

            Diarrhea, dyspepsia, nausea, vomiting

            Hyperoxaluria (large doses)

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Renal impairment, G6PD deficiency (high doses)

            Use of parenteral preparation in nursing women

            Patients with history of renal calculi should avoid taking excessive doses for extended periods of time

            Solutions exposed to air rapidly oxidized

            Patients with diabetes mellitus should not take excessive doses for extended periods of times

            Destroyed by sunlight

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            Pregnancy & Lactation

            Pregnancy Category: A (dose within RDA); C (dose exceeding RDA recommendation)

            Lactation: Enters breast milk/compatible

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Nutrition

            Sources: Citrus fruits, peppers, cabbage, papaya, orange juice, broccoli, guava, carambola, radishes

            Function: Required for collagen biosythesis

            Deficiency: Scurvy; fatigue, depression, easy bruising & bleeding, weakened cartilage, coiled hairs, difficulty wound healing, thickened skin, abnormal bone growth in infants

            Toxicity: Potential for kidney stones, withdrawal from high doses can lead to scurvy, even with "normal" intake

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            Pharmacology

            Mechanism of Action

            Necessary for collagen formation and tissue repair; plays a role in oxidation/reduction reactions as well as other metabolic pathways including synthesis of catecholamines, carnitine, and steroids; also plays a role in conversion of folic acid to folinic acid

            Pharmacokinetics

            Distribution: Large

            Metabolism: Liver

            Absorption: Rapidly absorbed

            Excretion: Urine

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            Administration

            When oral administration is not feasible or when malabsorption is suspected

            IM preferred to IV

            IV Preparation

            Dilute with large volume of compatible fluid to minimize adverse reactions

            Compatible w/ most common diluents (dextrose solns, NS, LR, Ringer's, ½NS, dextrose-saline, dextrose-LR etc)

            IV Administration

            Avoid rapid infusion

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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