human papillomavirus vaccine, bivalent (Rx) - Cervarix, hpv vaccine, bivalent

 
 
 

Adult Dosing & Uses

Cervical Cancer Prevention

Indicated for prevention of cervical precancers & cervical cancer associated with oncogenic HPV types 16 & 18

Girls & women (9-25 years old): 0.5 mL IM x3 doses at 0, 1, and 6 months (FDA approved labeled dose)

CDC recommendations

  • Girls and women aged 9-26 years: 0.5 mL IM for 3 doses administered at schedule of 0, 2, and 6 mo
  • CDC recommends routine vaccination at age 11 or 12 yr with either HPV2 or HPV4; may begin vaccination series as early as age 9 yr
  • If age 26 y reached before vaccination series completed, remaining doses can be administered after age 26 yr

Indicated for prevention of the following diseases caused by HPV types 16 & 18

  • Cervical cancer
  • Cervical intraepithelial neoplasia (CIN grade 2 or worse)
  • Adenocarcinoma in situ
  • Cervical intraepithelial neoplasia (CIN) grade 1

Other Information

Inject IM in deltoid region of upper arm

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Pediatric Dosing & Uses

Cervical Cancer Prevention

Indicated for prevention of cervical precancers and cervical cancer associated with oncogenic HPV types 16 & 18

Girls & women (9-25 years old): as adults; 0.5 mL IM x3 doses at 0, 1, and 6 months (FDA approved labeled dose)

CDC recommendations

  • Girls and women aged 9-26 years: 0.5 mL IM for 3 doses administered at schedule of 0, 2, and 6 mo
  • CDC recommends routine vaccination at age 11 or 12 y with either HPV2 or HPV4; may begin vaccination series as early as age 9 yr

Indicated for prevention of the following diseases caused by HPV types 16 & 18

  • Cervical cancer
  • Cervical intraepithelial neoplasia (CIN grade 2 or worse)
  • Adenocarcinoma in situ
  • Cervical intraepithelial neoplasia (CIN) grade 1

Other Information

Inject IM in deltoid region of upper arm

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Drug Interactions

Interaction Checker

human papillomavirus vaccine, bivalent and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Injection site pain, erythema, & inflammation

            Fatigue

            Headache

            Myalgia

            GI symptoms

            Arthralgia

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            Contraindications & Cautions

            Contraindications

            Hypersensitivity

            Prefilled syringes in pt w/ latex allergy

            Cautions

            Not recommended during pregnancy (safety not established)

            Syncope may occur, observe for 15 min after administration

            Tonic/clonic movements and other seizure-like activity has been reported (if associated w/ seizure, usually transient & responds to supine or Trendelenburg position)

            Immunocompromised pt may have decrease response to vaccine

            Do not mix with other vaccines in same syringe or vial

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            View Category Definitions

            Pregnancy & Lactation

            Pregnancy category: B

            Lactation: Unknown whether distributed in breast milk; use with caution

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Duration: unknown

            Mechanism of Action

            Recombinant vaccine prepared from L1 protein of HPV types 16 & 18

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            IV & IM Information

            IM Preparation

            Shake vial/syringe well before withdrawal and administration

            Storage

            Store refrigerated be 2-8 degrees Centigrade

            Do not freeze

            Fine, white deposit with a clear, colorless supernatant may be observed (does not constitute deterioration)

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            Pricing & Images

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