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diphenhydramine/phenylephrine (OTC)Brand and Other Names:Children's Dimetapp Nighttime Cold & Congestion

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

diphenhydramine/phenylephrine

oral liquid

  • (6.25mg/2.5mg)/5mL
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Cold/Congestion

Indicated for symptoms occurring with a cold, hay fever, or other upper respiratory allergies

4 teaspoonfuls (ie, 20 mL) PO q4hr PRN

Dosage Forms & Strengths

diphenhydramine/phenylephrine

oral liquid

  • (6.25mg/2.5mg)/5mL
more...

Cold/Congestion

Indicated for symptoms occurring with a cold, hay fever, or other upper respiratory allergies

<6 years: Do not use

6-12 years: 2 teaspoonfuls (ie, 10 mL) PO q4hr PRN

12 years or older: 4 teaspoonfuls (ie, 20 mL) PO q4hr PRN

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Interactions

Interaction Checker

diphenhydramine/phenylephrine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Hypertension

            Severe peripheral and visceral vasoconstriction

            Reflex tachycardia

            Dizziness

            Drowsiness

            Excitability

            Headache

            Restlessness

            Tremor

            GI disturbances

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            Warnings

            Contraindications

            Hypersensitivity

            Repeated administration in patients with anemia or cardiac, pulmonary, or renal disease

            Do not use with MAOIs or for 2 weeks after discontinuing MAOIs

            Cautions

            Phenylephrine may increase blood pressure

            Diphenhydramine

            • Marked drowsiness may occur; avoid other sedating drugs and alcohol
            • Paradoxical excitability reaction may occur, especially in children
            • Caution in narrow angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction
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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown; use with caution

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Diphenhydramine: Histamine H1-receptor antagonist

            Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia

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