dextromethorphan/phenylephrine (OTC)

Brand and Other Names:Children's Sudafed PE Cold & Cough, Children's Triaminic Day Time Cold & Cough Thin Strips, more...PediaCare Children's Multi-Symptom Cold, PediaCare Infant Decongestant & Cough (PE) Oral Drops, Theraflu Daytime Cold & Cough Strips, Triaminic Daytime Cold & Cough Liquid, Vicks Formula 44 Custom Care Congestion
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

dextromethorphan/phenylephrine

strips

  • 3.67mg/2.5mg

oral solution

  • (5mg/2.5mg)/1mL

Syrup

  • (5mg/2.5mg)/5mL
  • (15mg/2.5mg)/5mL

liquid

  • (5mg/2.5mg)/5mL
  • (20mg/10mg)/15mL
more...

Relief of Mild to Moderate Pain & Congestion, Flu Symptoms & Common Cold

2 strips (3.67mg/2.5mg) PO q4hr; not to exceed 12/day

15 mL [(20mg/10mg)/15mL] PO q4hr; not to exceed 90 mL/day

10 mL [(15mg/2.5mg)/5mL] PO q6hr; not to exceed 40 mL/day

Dosage Forms & Strengths

dextromethorphan/phenylephrine

strips

  • 3.67mg/2.5mg

oral solution

  • (5mg/2.5mg)/1mL

Syrup

  • (5mg/2.5mg)/5mL
  • (15mg/2.5mg)/5mL

liquid

  • (5mg/2.5mg)/5mL
  • (20mg/10mg)/15mL
more...

Relief of Mild to Moderate Pain & Congestion, Flu Symptoms & Common Cold

<4 years

  • Ask a pediatrician

4-6 years

  • 1mL [(5mg/2.5mg)/1mL] PO q4hr; not to exceed 6 mL/day
  • 1 strip (3.67mg/2.5mg) PO q4hr; not to exceed 6/day
  • 5 mL [(5mg/2.5mg)/5mL] PO q4hr; not to exceed 30 mL/day
  • Safetussin CD Liquid: 2.5 mL q6hr; not to exceed 10 mL/day

6-12 years

  • 2 mL [(5mg/2.5mg)/1mL] PO q4hr; not to exceed 6 mL/day
  • 2 strips (3.67mg/2.5mg) PO q4hr; not to exceed 12/day
  • 10 mL [(5mg/2.5mg)/5mL] PO q4hr; not to exceed 60 mL/day
  • 7.5 mL [(20mg/10mg)/15mL] PO q4hr; not to exceed 45 mL/day

>12 years

  • 2 strips (3.67mg/2.5mg) PO q4hr; not to exceed 12/day
  • 15 mL [(20mg/10mg)/15mL] PO q4hr; not to exceed 90 mL/day
  • 10 mL [(15mg/2.5mg)/5mL] PO q6hr; not to exceed 40 mL/day
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Interactions

Interaction Checker

and dextromethorphan/phenylephrine

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            Adverse Effects

            Frequency Not Defined

            Hypertension

            Severe peripheral and visceral vasoconstriction

            Reflex tachycardia

            Dizziness

            Drowsiness

            Excitability

            Headache

            Restlessness

            Tremor

            GI disturbances

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            Warnings

            Contraindications

            Contraindicated in documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy

            Cautions

            Not to be administered to children without the guidance of a physician if no recommendations described in the OTC product labeling

            Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required

            Do not take dextromethorphan for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; dextromethorphan may slow the breathing

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in milk unknown; use with caution

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Dextromethorphan is a cough suppressant that acts centrally on the cough center in the medulla.

            Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.

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            Images

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