Huperzine A (Herbs/Suppl)

Brand and Other Names:Chinese club moss, Huperzine Rx-Brain, more...HUP, HUP A, Memorall, selagine
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Suggested Dosing

Alzheimer's disease & Multi-infarct dementia

50-200 mcg PO BID

Senile or presenile dementia

30 mcg PO BID

Prevention of muscle weakness in myasthenia gravis

400 mcg IM qDay

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Suggested Uses

Improve memory; treatment of Alzheimer's disease, protection from neurotoxic agents including organophosphate nerve gases, glutamate toxicity, and treating myasthenia gravis

Efficacy

Clinical studies in progress; preliminary results promising

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Interactions

Interaction Checker

and Huperzine A

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Gastrointestinal effects (eg, nausea, diarrhea)

            Sweating

            Blurred vision

            Fasciculations

            Dizziness

            See cholinergic syndrome

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            Warnings

            Contraindications

            Seizure disorders, cardiac arrhythmias, asthma, IBS, IBD & malabsorption syndromes

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            Pregnancy & Lactation

            Pregnancy Category: avoid

            Lactation: avoid

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Absorption: readily from GI tract

            Distribution: wide, including brain

            Peak Plasma Time: 80 min

            Metabolism: some first pass metabolism in liver

            Excretion: N/A

            Mechanism of Action

            Cholinesterase inhibitor

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