secretin (Rx)

Brand and Other Names:ChiRhoStim
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

powder for injection

  • 16 mcg/vial
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Pancreas Dysfunction

Secretin stimulation testing for diagnosis of pancreatic exocrine dysfunction

0.2 mcg/kg IV over 1 minute

Gastrinoma

Secretin stimulation testing for diagnosis of gastrinoma

0.4 mcg/kg IV over 1 minute

Ampulla of Vater & Accessory Papilla

Secretin stimulation testing for identification of ampulla of Vater and accessory papilla during ERCP

0.2 mcg/kg IV over 1 minute

Safety and efficacy not established

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Adverse Effects

<1%

Hypotension

Diaphoresis

Flushing

Abdominal pain

Bleeding

Abdominal cramps

Bloating

Bradycardia

Nausea

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Warnings

Contraindications

Hypersensitivity

Acute pancreatitis

Cautions

Test dose of 0.2 mcg (0.1 ml) IV to check for allergic reaction (wait 1 min)

Prior vagotomy, current anticholinergic prescription, or IBD may blunt response to secretin stimulation

Alcoholic or other liver disease may lead to greater than normal volume in response to secretin stimulation

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Pregnancy & Lactation

Pregnancy: There are no available data on porcine secretin use in pregnant women to inform a drug-associated risk

Lactation: There are no data on presence of porcine secretin in human milk; the effects of porcine secretin on breastfed infant, or effects of porcine secretin on milk production; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Porcine Secretin for Injection and any potential adverse effects on the breastfed infant from porcine secretin or from the underlying maternal condition

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Peptide hormone; increase volume and bicarb content of pancreatic secretions

Pharmacokinetics

Half-Life: 27 min

Vd: 2 L

Total Body Clearance: 487±136 mL/min

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Administration

IV Administration

Reconstitute by adding 8 mL of NS to a vial containing 16 mcg of secretin to yield 2 mcg/mL; shake vigorously to ensure complete dissolution

Slow IV injection over 1 min

Storage

Store at -20°C

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
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  • Compare formulary status to other drugs in the same class.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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