chromium (OTC)

Brand and Other Names:chromium 3, chromium picolinate, more...glucose tolerance factor, trivalent chromium
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Dosing & Uses

AdultPediatric

Adequate Intake

Males (14-50 years old): 35 mcg/day; (> 50 years old): 30 mcg/day;

Females (19-50 years old): 25 mcg/day; (>50 years old): 20 mcg/day;

Pregnant 30 mcg/day;

Lactation 45 mcg/day

Diabetes Mellitus, Type 2

200-1000 mcg/day PO in divided doses

Beta Blocker-Related Low HDL Cholesterol

200 mcg PO TID

Hyperglycemia, Corticosteroid-Induced

200 mcg PO TID, OR

400 mcg PO qDay

Hypoglycemia, Prevention

200 mcg PO qDay

Dysthymic Disorder

200 mcg PO qDay-BID

Other Indications & Uses

Weight loss, type 2 diabetes, hypercholesterolemia, athletic performance enhancement, dysthymic disorder, hyperglycemia, hypoglycemia (reactive), low HDL cholesterol (beta blocker-related), muscle mass builder

Efficacy

  • Possibly effective in lowering blood lipids, maintaining glycemic control
  • Likely ineffective for weight loss

Adequate Intake

0-6 months old: 0.2 mcg/day

7-12 months old: 5.5 mcg/day

1-3 years old: 11 mcg/day

4-8 years old: 15 mcg/day

9-13 years old: 21 mcg/day (female), 25 mcg/day (male)

14-18 years old (female): 21 mcg/day

Polycystic Ovary Syndrome (Orphan)

Orphan designation for chromium picolinate and chromium histidinate for treatment of pediatic polycystic ovary syndrome (aged ≤16 yr)

Sponsor

  • JDS Therapeutics, LLC; 3 Manhattanville Rd, Suite 201; Purchase, NY 10577
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Interactions

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and chromium

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    Contraindicated

      Serious - Use Alternative

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            Adverse Effects

            Frequency Not Defined

            Common

            • Cognitive dysfunction, headache, insomnia, irritability, mood changes, motor dysfunction, perceptual dysfunction, sleep disturbances
            • Weight gain (high dose)
            • Anemia, hemolysis, thrombocytopenia

            Rare

            • Renal/liver impairment (high dose)
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            Warnings

            Contraindications

            Chromate allergy, leather contact allergy, impaired renal fxn, breastfeeding (high dose)

            Cautions

            Psychiatric or behavioral disorders (high dose)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: renal, biliary

            Mechanism of Action

            Enhances insulin receptor sensitivity in peripheral cells (component of glucose tolerance factor)

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