2-4 g/d PO
Diarrhea, mucous colitis, gall bladder disease associated with gastric hyperacidity, sore throat
Serious - Use Alternative
Significant - Monitor Closely
No serious ADRs reported
Larger than recommended doses can cause constipation & other GI problems
Possible increased risk of tongue & lip cancer at high doses
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Contains tannins that tone mucous membranes, improving secretion & absorption
Efficacy: no human studies