Resveratrol (Herbs/Suppl)

Brand and Other Names:cis-resveratrol, kojo-kon, more...Stilbene phytoalexin, trans-resveratrol
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Suggested Dosing

10-200 mg/day PO

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Suggested Uses

Atherosclerosis, hypercholesterolemia, cancer prevention

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Adverse Effects

None reported

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Warnings

Contraindications

Hypersensitivity

Pregnancy (red wine)

Cautions

None reported

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Pregnancy & Lactation

Pregnancy Category: avoid red wine

Lactation: unknown; not recommended

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Polyphenol found in grape skins, dark red wines; supplements usually derived from Japanese knotweed (Polygonium cuspidatum)

Antioxidant, antiplatelet, antimutagenic, and phytoestrogenic properties

Inhibits COX 1 & 2 and 5-lipoxygenase

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