10-200 mg/day PO
Atherosclerosis, hypercholesterolemia, cancer prevention
Pregnancy (red wine)
Pregnancy & Lactation
Pregnancy Category: avoid red wine
Lactation: unknown; not recommended
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Polyphenol found in grape skins, dark red wines; supplements usually derived from Japanese knotweed (Polygonium cuspidatum)
Antioxidant, antiplatelet, antimutagenic, and phytoestrogenic properties
Inhibits COX 1 & 2 and 5-lipoxygenase