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cefotaxime (Rx)Brand and Other Names:Claforan

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 20mg/mL
  • 40mg/mL

powder for injection

  • 500mg
  • 1g
  • 2g
  • 10g
more...

Gonococcal Urethritis/Cervicitis

0.5 g IM once

Gonorrhea, Rectal

Men: 1 g IM once

Women: 0.5 g IM once

Infections Caused by Susceptible Organisms

Uncomplicated: 1 g IV or IM q12hr

Moderate to severe: 1-2 g IV or IM q8hr

More serious (bloodstream infection [septicemia]): 2 g IV q6-8hr

Life-threatening: 2 g IV q4hr; not to exceed 12 g/day

Preparation for Surgery

Prophylaxis of surgical infection

1 g IM/IV once 30-90 minutes before start of procedure

Dosing Considerations

Susceptible organisms

  • Bacteroides spp, Citrobacter spp, Clostridium spp, Enterobacter spp, Escherichia coli, Haemophilus influenzae, Klebsiella spp, Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Peptococcus spp, Peptostreptococcus spp, Proteus mirabilis, Providencia rettgeri, Pseudomonas spp, Serratia spp, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes

Dosage Forms & Strengths

injectable solution

  • 20mg/mL
  • 40mg/mL

powder for injection

  • 500mg
  • 1g
  • 2g
  • 10g
more...

Infections Caused by Susceptible Organisms

<12 years or <50 kg: 50-200 mg/kg/day IV/IM divided q6-8hr 

>12 years or >50 kg: 1-2 g IV/IM q8hr

Epiglottitis

<12 years or <50 kg: 150-200 mg/kg/day IV/IM divided q6hr plus clindamycin for 7-10 days 

>12 years or >50 kg: 1-2 g IV/IM q8hr

Meningitis

<12 years or <50 kg: 200 mg/kg/day IV/IM divided q6hr 

>12 years or >50 kg: 2 g IV q4-6hr in combination with other antimicrobial therapy as necessary

Pneumonia

<12 years or <50 kg: 200 mg/kg/day IV divided q8hr 

>12 years or >50 kg: 1-2 g IV/IM q8hr

Sepsis

<12 years or <50 kg: 150 mg/kg/day IV divided q8hr 

>12 years or >50 kg: 2 g IV q6-8hr

Typhoid Fever

<12 years or <50 kg: 150-200 mg/kg/day IV/IM divided q6-8hr; not to exceed 12 g/day 

Fluoroquinolone resistant: 80 mg/kg/day IV/IM divided q6-8hr; not to exceed 12 g/day

>12 years or >50 kg: 1-2 g IV/IM q4-8hr

Dosing Considerations

Usual dosage range in children

  • 0-1 week: 50 mg/kg IV q12hr
  • 1-4 weeks: 50 mg/kg IV q8hr
  • 1 month-12 years: 50-180 mg/kg/day IV divided q4-6hr
  • >12 years: 1-2 g IV/IM q4-8hr
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Interactions

Interaction Checker

cefotaxime and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
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            Adverse Effects

            Frequency Not Defined

            Colitis

            Diarrhea

            Elevated blood urea nitrogen (BUN) and creatinine

            Elevated hepatic transaminases

            Eosinophilia

            Fever

            Injection site pain

            Nausea

            Pruritus

            Rash

            Thrombocytopenia

            Transient neutropenia

            Vomiting

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            Warnings

            Contraindications

            Documented hypersensitivity to drug or components

            Cautions

            Potentially life-threatening arrhythmia reported in patients receiving rapid bolus injection through central venous catheter

            Prolonged treatment has been associated with granulocytopenia (>10 days)

            Change infusion sites to minimize inflammation

            Use with caution in patients with history of penicillin allergy

            Use with caution in patients with history of colitis

            Bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapy

            May need to adjust dose in renal impairment

            Cefotaxime may potentiate the nephrotoxic effects of nephrotoxic drugs, including aminoglycosides, NSAIDs, and furosemide

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            Pregnancy & Lactation

            Pregnancy category: B

            Lactation: Drug enters breast milk; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Binds to penicillin-binding proteins and inhibits final transpeptidation step of peptidoglycan synthesis, resulting in cell-wall death; resists degradation by beta-lactamase; proper dosing and appropriate route of administration are determined by condition of patient, severity of infection, and susceptibility of microorganism

            Absorption

            Peak plasma time: IM, 30 min

            Distribution

            Distribution: widely distributed to body tissues and fluids, including aqueous humor, ascitic and prostatic fluids, bone, penetrates CSF when meninges inflamed

            Widely distributed to body tissues and fluids, including aqueous humor, ascitic and prostatic fluids, and bone; penetrates CSF when meninges are inflamed

            Metabolism

            Partially metabolized in liver

            Metabolite: Desacetylcefotaxime (active)

            Elimination

            Half-life: Parent drug, 1-1.5 hr; active metabolite, 1-1.9 hr

            Excretion: Urine

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            Administration

            IV Incompatibilities

            Additive: Aminoglycosides, aminophylline, sodium bicarbonate

            Syringe: Doxapram

            Y-site: Allopurinol, filgrastim, fluconazole, gemcitabine, hetastarch, pentamidine

            IV Preparation

            Intermittent injection: Reconstitute 1 or 2 g with 10 mL SWI

            Infusion: Reconstitute infusion bottles with 50 or 100 mL NS or D5W

            May be diluted further

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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