loratadine (OTC)

Brand and Other Names:Claritin, Claritin RediTabs, more...QlearQuil All Day & All Night 24 Hour Allergy Relief
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

syrup

  • 5mg/5mL

tablet

  • 10mg

tablet, chewable

  • 5mg

tablet, disintegrating

  • 5mg
  • 10mg

capsule

  • 10mg
more...

Allergic Rhinitis

10 mg PO qDay or 5 mg twice daily; not to exceed 10 mg qDay

Urticaria

10 mg PO qDay; not to exceed 10 mg qDAy

Dosing Considerations

Renal impairment (GFR <30 mL/min): 10 mg PO every other day

Hepatic impairment: 10 mg PO every other day

Administration

Claritin RediTabs: Dissolve on tongue

Dosage Forms & Strengths

syrup

  • 5mg/5mL

tablet

  • 10mg

tablet, chewable

  • 5mg

tablet, disintegrating

  • 5mg
  • 10mg

capsule

  • 10mg
more...

Allergic Rhinitis

<2 years: Safety and efficacy not established

2-6 years: 5 mg PO qDay

>6 years: 10 mg PO qDay; not to exceed 10 mg qDay

Urticaria

<6 years: Safety and efficacy not established

> 6 years: 10 mg PO qDay

Dosing Modifications

Renal impairment (GFR <30 mL/min)

  • 2-6 years: 5 mg PO every other day
  • >6 years: 10 mg PO every other day

Hepatic impairment

  • 2-6 years: 5 mg PO every other day
  • >6 years: 10 mg PO every other day

Administration

Claritin RediTabs: Dissolve on tongue

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Interactions

Interaction Checker

and loratadine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Headache (12%)

            1-10%

            Somnolence (8%)

            Drowsiness (8%)

            Nervousness (4%)

            Fatigue (3-4%)

            Dry mouth (3%)

            Hyperkinesia (3%)

            Conjunctivitis (2%)

            Dysphonia (2%)

            Malaise (2%)

            URTI (2%)

            Abdominal pain (2%)

            Frequency Not Defined

            Autonomic nervous system: Altered lacrimation, altered salivation, flushing, hypoesthesia, impotence, increased sweating, thirst

            Cardiovascular: HTN, hypotension, palpitations, supraventricular tachyarrhythmias, syncope, tachycardia

            CNS: Blepharospasm, dizziness, dysphonia, hypertonia, migraine, paresthesia, tremor, vertigo

            GI: Altered taste, anorexia, constipation, diarrhea, dyspepsia, flatulence, gastritis, hiccup, increased appetite, loose stools, nausea, vomiting

            Musculoskeletal: Arthralgia, myalgia

            Psychiatric: Agitation, amnesia, anxiety, confusion, decreased libido, depression, impaired concentration, insomnia, irritability, paroniria

            Reproductive: Breast pain, dysmenorrhea, menorrhagia, vaginitis

            Respiratory: Bronchitis, bronchospasm, coughing, dyspnea, hemoptysis, laryngitis, nasal dryness, sinusitis, sneezing

            Skin: Dermatitis, dry hair, dry skin, photosensitivity reaction, pruritus, purpura, urticaria

            Urinary: Altered micturition, urinary discoloration, urinary incontinence, urinary retention

            Other

            • Angioneurotic edema
            • Asthenia
            • Back pain
            • Blurred vision
            • Chest pain
            • Earache
            • Eye pain
            • Fever
            • Leg cramps
            • Malaise
            • Rigors
            • Tinnitus
            • Weight gain
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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Caution in hepatic and renal impairment

            Elderly patients are at increased risk for comorbidities related to anticholinergic effects; may be potentially inappropriate in this population (Beers criteria)

            Effects of ethanol and other sedative drugs may be potentiated when used concurrently

            Benzyl alcohol, which is associated with the fatal toxicity, gasping syndrome in neonates; use caution

            Some products may contain phenylalanine

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            Pregnancy & Lactation

            Pregnancy category: B

            Lactation: Excreted in breast milk; avoid (AAP Committee states compatible with nursing)

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Long-acting tricyclic antihistamine with selective peripheral histamine H1-receptor antagonistic activity

            Absorption

            Onset: 1-3 hr

            Peak effect: 8-12 hr

            Duration : 24 hr

            Metabolism

            Hepatic CYP3A4 (major), CYP2D6 (minor)

            Metabolites: Descarboethoxyloratadine

            Elimination

            Half-life: 12-15 hr

            Excretion: Urine (40%); feces (40%)

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            Images

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