clevidipine (Rx)

Brand and Other Names:Cleviprex
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

infusion solution

  • 0.5mg/mL
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Hypertension

1-2 mg/hr (2-4 mL/hr), double dose q90sec initially; as blood pressure approaches goal, increase dose by less than doubling, and increase time between adjustments to q5-10min 

Maintenance: 4-6 mg/hr; not to exceed 21 mg/hr (1000 mL within 24 hour period)

Renal Impairment

Dose adjustment not necessary

Hepatic Impairment

Dose adjustment not necessary

Safety and efficacy not established

Initiate dosing at the low end of the dosage range

Hypertension

1-2 mg/hr (2-4 mL/hr), double dose q90sec initially; as blood pressure approaches goal, increase dose by less than doubling, and increase time between adjustments to q5-10min 

Maintenance: 4-6 mg/hr; not to exceed 21 mg/hr (1000 mL within 24 hour period)

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Interactions

Interaction Checker

and clevidipine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            AFib (21%)

            Nausea (21%)

            1-10%

            Acute renal failure (9%)

            Headache (6%)

            Vomiting (3%)

            <1%

            Cardiac arrest

            Myocardial infarction

            Postmarketing Reports

            Increased blood triglycerides

            Ileus

            Nausea

            Hypersensitivity

            Hypotension

            Reflex tachycardia

            Decreased oxygen saturation (possible pulmonary shunting)

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            Warnings

            Contraindications

            Hypersensitivity to drug, soy or egg products

            Defective lipid metabolism

            Acte pancreatitis if accompanied by hyperlipidemia

            Severe aortic stenosis

            Cautions

            CHF

            Risk of hypotension & reflex tachycardia

            Contains no preservatives

            Potential for rebound HTN after stoppage of prolonged infusion

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Not known if excreted into breast milk, do not nurse

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Calcium channel blocker (dihydropyridine): inhibits transmembrane influx of extracellular Ca ions across membranes of myocardial cells and vascular smooth muscle cells, without changing serum calcium concentrations, resulting in inhibition of cardiac and vascular smooth muscle contraction, thereby dilating main coronary and systemic arteries

            Pharmacokinetics

            Onset: 2-4 minutes

            Protein Bound: 99.5%

            Metabolized in blood and extravascular tissues

            Half-Life: Initial 1 minute; terminal 15 minutes

            Excretion: Urine (63-74%); feces (7-22%)

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            Administration

            IV Compatibilities

            Not diluted but compatible w/ following solvents: SWI; NS; D5W; D5/NS; D5/LR; LR; 10% aminoacid

            IV Administration

            Milky white emulsion

            No preservatives-use within 4 hr of puncturing stopper

            Doesn't need dilution

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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