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docusate (OTC)Brand and Other Names:Colace, DSS, more...Albert Docusate, Docusate Calcium, docusate sodium, DulcoEase, Phillips Liqui Gels, Silace, Soflax

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule as sodium

  • 50mg
  • 100mg
  • 250mg

capsule as calcium

  • 240mg

tablet

  • 100mg

oral liquid

  • 10mg/mL
  • 50mg/15mL

syrup

  • 60mg/15mL

Enema, Rectal (Sodium)

  • 283 mg (5 mL)
more...

Stool Softener

Oral

  • Docusate sodium: 50-300 mg PO once daily or divided doses
  • Docusate calcium: 240 mg PO qDay

Rectal

  • 283 mg/5mL (1 enema) PR once daily to three times daily

Dosage Forms & Strengths

capsule as sodium

  • 50mg
  • 100mg
  • 250mg

capsule as calcium

  • 240mg

oral liquid

  • 10mg/mL
  • 50mg/15mL

syrup

  • 60mg/15mL

Enema, Rectal (Sodium)

  • 100mg/5mL
  • 283 mg (5 mL)
more...

Stool Softener

Oral

  • Docusate sodium
    • <2 years: Safety & efficacy not established
    • 2-12 years: 50-150 mg PO qDay or divided doses
    • >12 years: 50-300 mg PO once daily or divided doses
  • Docusate calcium
    • <12 years: Safety & efficacy not established
    • >12 years: 240 mg PO qDay

Rectal

  • <2 years: Safety & efficacy not established
  • 2-12 years: 100 mg/5 mL (1 enema) PR qDay; alternatively, 283 mg/5 mL (1 enema) PR qDay
  • >12 years: 283 mg/5mL (1 enema) PR once daily to three times daily
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Interactions

Interaction Checker

docusate and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abdominal cramping

            Diarrhea

            Excessive bowel activity

            Intestinal obstruction

            Throat irritation

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            Warnings

            Contraindications

            Hypersensitivity

            Intestinal obstruction, symptoms of appendicitis or acute abdominal pain, fecal impaction

            Concomitant use of mineral oil

            Nausea or vomiting

            Use for longer than 7 days when self-medicating

            Cautions

            Electrolyte imbalance may occur with excessive use

            Excessive use may result in dependence

            Enema is for rectal use only; lubricate prior to insertion; discontinue use and notify health care professional if irritation occurs around the anus/rectal or if resistance is encountered with insertion; injury or damage to the rectum can occur if tube forced

            Prior to OTC use, patient should contact healthcare professional if stomach pain, nausea, or vomiting are present, or if a sudden change in bowel habits occurs and persists over 14 days

            Patient should discontinue use and notify healthcare professional if bleeding occurs, if bowel movement fails to occur after use, or need to continue use after using for 7 days

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Unknown whether drug is excreted in milk; compatible with nursing

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Surfactant laxative, reduces tension of oil-water interface of the stool; enhances incorporation of water and fat into stool, causing stool to soften

            Absorption

            Onset: 24-72 hr

            Elimination

            Excretion: Feces

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