colestipol (Rx)

Brand and Other Names:Colestid
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

granules, bottle

  • 5g

granules, packets

  • 5g

tablet

  • 1g
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Hyperlipidemia

Tablets: 2 g PO qDay or q12hr; increases of 2 g should occur at 1- or 2-month intervals; titrate not to exceed 16 g/day

Granules: 5 g PO qDay; increases of 5 g should occur at 1- or 2-month intervals; titrate not to exceed 30 g/day

Overdose Management

Generally considered safe in acute overdose although not formally studied

Adverse drug reactions in overdose may include peripheral neuropathy, diarrhea, increase K+, myopathy , rhabdomyolysis, acute renal failure, elevated liver function tests, eye lens opacities)

Check renal function tests, urine myoglobin, CPK, LFT's

Administration

Mix dry form in water/fluids to avoid inhalation or esophageal distress

Mix granules in fluids or food; take before meals

Do not crush, chew, or cut tablets

Take 1 tablet at a time; swallow with water or other fluids

Other Information

Monitor: Serum cholesterol, triglycerides

Other Indications & Uses

Used in relief of pruritus associated with elevated levels of bile

Used to decrease plasma half-life of digoxin in toxicity

Hypercholesterolemia (adjunct to diet for Type IIa & IIb hyperlipidemia)

Safety & efficacy not established

Tablets: 2 g PO qDay or q12hr; increases of 2 g should occur at 1- or 2-month intervals; titrate not to exceed 16 g/day

Granules: 5 g PO qDay; increases of 5 g should occur at 1- or 2-month intervals; titrate not to exceed 30 g/day

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Interactions

Interaction Checker

and colestipol

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Gastrointestinal (mostly)

            Constipation

            1-10%

            Stomach pain

            Belching

            Nausea/vomiting

            Flatulance

            Diarrhea

            Dizziness

            Anxiety

            Vertigo

            Fatigue

            Drowsiness

            Frequency Not Defined

            Heartburn

            Steatorrhea

            Malabsorption of fat-soluble vitamins

            Gallstones

            Dysphagia

            GI bleeding

            Cholecystitis

            Peptic ulceration

            Transient esophageal obstruction

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            Warnings

            Contraindications

            Hypersensitivity to colestipol

            Bowel obstruction

            Cautions

            Increased risk of bleeding due to hypoprothrombinemia from vitamin K deficiency

            May interfere with fat absorption, and decrease absorption of fat-soluble vitamins (A, D, E, K)

            May worsen pre-existing constipation

            Take other medications 1 hr before or 4 hr after colestipol

            If significant increase in triglycerides, consider dose reduction, discontinuation or alternatives

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: use caution; may interfere with vitamin absorption in infants

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Forms a soluble complex after binding to bile acid, increasing fecal loss of bile acid-bound low-density lipoprotein cholesterol

            Pharmacokinetics

            Onset: initial effect: 24-48 hr; max effect: 1 wk

            Bioavailability: Not absorbed

            Metabolism: Not metabolized

            Excretion: feces 100%

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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