100-300 mg/day PO of extract containing 10-20% forskolin
Asthma: 10 mg of forskolin powder; use a Spinhaler inhalator
Cancer, obesity, glaucoma, allergies & asthma; heart failure, intestinal spasms, dysmenorrhea, IBS, UTI, hypertension, angina, insomnia, & convulsions
Small clinical studies indicate obesity reduction potential as well as asthma prevention
Serious - Use Alternative
Significant - Monitor Closely
Hypotension (with beta-blockers, vasodilators, calcium channel blockers), tachycardia, bleeding
Concurrent anticoagulants, antihypertensives, vasodilators
Risk of bleeding
Pregnancy & Lactation
Pregnancy Category: avoid use
Lactation: avoid use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Promotes activation of adenylate cyclase & incr intracellular cAMP resulting in beta-adrenergic effects:
- positive inotrope
- inhibits Plt aggregation