timolol/brimonidine (Rx)Brand and Other Names:Combigan

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

timolol/brimonidine

ophthalmic solution

  • (5mg/2mg)/mL (0.5%/0.2%)
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Elevated IOP in Patients with Glaucoma or Ocular Hypertension

1 gtt in affected eye(s) BID approximately 12 hours apart

Dosage Forms & Strengths

timolol/brimonidine

ophthalmic solution

  • (5mg/2mg)/mL (0.5%/0.2%)
more...

Elevated IOP in Patients with Glaucoma or Ocular Hypertension

<2 years: Contraindicated

≥2 years old: 1 gtt in affected eye(s) BID approximately 12 hours apart

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Interactions

Interaction Checker

timolol/brimonidine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            5-15%

            Allergic conjunctivitis

            Conjunctival folliculosis

            Conjunctival hyperemia

            Eye pruritus

            Ocular burning

            Stinging

            1-5%

            Asthenia

            Blepharitis

            Corneal erosion

            Depression

            Epiphora

            Eye discharge

            Eye dryness

            Eye irritation

            Eye pain

            Eyelid edema

            Eyelid erythema

            Eyelid pruritus

            Foreign body sensation

            Headache

            Hypertension

            Oral dryness

            Somnolence

            Superficial punctate keratitis

            Visual disturbance

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            Warnings

            Contraindications

            Hypersensitivity to either product or other components

            Reactive airway disease, including severe COPD or active or history of bronchial asthma

            Sinus bradycardia, 2°/3° AV block, overt cardiac failure, cardiogenic shock

            Concurrency with MAO inhibitors

            Cautions

            Not to be used alone for acute angle-closure glaucoma

            Depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thromboangiitis obliterans, diabetes mellitus, severe cardiovascular dz, renal/hepatic impairment, myasthenia gravis

            Ocular hypersensitivity reported with brimonidine ophthalmic solutions; including some reports with Increased IOP

            If other eye drops used, instill at least 5 min apart

            May mask hyperthyroidism/thyrotoxicosis symptoms

            Remove soft contact lenses; may reinsert 15 min post-instillation

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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