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hepatitis b vaccine/haemophilus influenzae type b vaccine (Rx)Brand and Other Names:Comvax, HIB/Hep B Vaccine

 
 
 

Dosing & Uses

AdultPediatric

Not for use in adults

Dosage Forms & Strengths

HIB cap polysaccharide/N. meningitides OMPC/HBsAg

injection suspension

  • (7.5 mcg/125 mcg//5mcg)/0.5 mL
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Immunization

Preferred: 0.5 mL IM at 2, 4, & 12-15 mo (3 doses) OR

Two 0.5 mL doses at 6-wk interval, followed by 3rd dose 8-11 months after 2nd dose

May be used in infants who have received 1 dose of hep B vaccine (recombinant) at birth

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Interactions

Interaction Checker

hepatitis b vaccine/haemophilus influenzae type b vaccine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

            >10%

            Injection site reactions (35%)

            Somnolence (21-50%)

            Unusual high pitch crying (3-11%)

            Fever (11-14%)

            Erytherma (22-27%)

            Pain/soreness (24-35%)

            1-10%

            Rash (≤1%)

            Anorexia (1-4%)

            Diarrhea (1-2%)

            Candidiasis (≤1%)

            Otitis media (<1-3%)

            Congestion (≤1%)

            Rhinorrhea (≤1%)

            Upper respiratory tract infection (≤1%)

            <1%

            Angioedema

            Febrile seizures

            Thrombocytopenia

            Urticaria

            Erythema multiforme

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            Warnings

            Contraindications

            Documented hypersensitivity to any component of the product

            Cautions

            Stopper contains natural rubber latex, which some individuals may be hypersensitive to

            Keep epinephrine handy in case of anaphylactic rxns

            Not for H. influenzae meninigitis or sepsis

            Do not give IV, SC or intradermally

            Caution in Guillain-Barre syndrome within 6 wk of prior tetanus toxoid vaccine

            Syncope accompanied by transient disturbances, tonic-clonic movements, or weakness reported

            Consider postponing administration iin patients with moderate or severe acute illness (with or without fever)

            Use caution in patients with a history of bleeding disorders (including thrombocytopenia) and or patients on anticoagulants

            Use caution in severely immunocompromised patients

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Not indicated for women of childbearing age

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Contains Hemophilus B capsular polysaccharide conjugated to meningococcal protein & Hepatitis B surface antigen which elicit antibody production & thereby impart immunity

            Conveys active immunity via stimulation of production of endogenously produced antibodies

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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