Brand and Other Names:Comvax, HIB/Hep B Vaccine
- Classes: Vaccines, Combos
Dosing & Uses
Not for use in adults
Dosage Forms & Strengths
HIB cap polysaccharide/N. meningitides OMPC/HBsAg
- (7.5 mcg/125 mcg//5mcg)/0.5 mL
Preferred: 0.5 mL IM at 2, 4, & 12-15 mo (3 doses) OR
Two 0.5 mL doses at 6-wk interval, followed by 3rd dose 8-11 months after 2nd dose
May be used in infants who have received 1 dose of hep B vaccine (recombinant) at birth
Serious - Use Alternative
Significant - Monitor Closely
Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967
Injection site reactions (35%)
Unusual high pitch crying (3-11%)
Otitis media (<1-3%)
Upper respiratory tract infection (≤1%)
Documented hypersensitivity to any component of the product
Stopper contains natural rubber latex, which some individuals may be hypersensitive to
Keep epinephrine handy in case of anaphylactic rxns
Not for H. influenzae meninigitis or sepsis
Do not give IV, SC or intradermally
Caution in Guillain-Barre syndrome within 6 wk of prior tetanus toxoid vaccine
Syncope accompanied by transient disturbances, tonic-clonic movements, or weakness reported
Consider postponing administration iin patients with moderate or severe acute illness (with or without fever)
Use caution in patients with a history of bleeding disorders (including thrombocytopenia) and or patients on anticoagulants
Use caution in severely immunocompromised patients
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Not indicated for women of childbearing age
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Contains Hemophilus B capsular polysaccharide conjugated to meningococcal protein & Hepatitis B surface antigen which elicit antibody production & thereby impart immunity
Conveys active immunity via stimulation of production of endogenously produced antibodies
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