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podofilox (Rx)Brand and Other Names:Condylox

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical solution/gel

  • 0.5%
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Anogenital Warts

Apply with cotton-tipped applicator (solution) or finger (gel) q12hr for 3 days then no treatment for 4 days

May repeat in 1 week, cycle up to 4 times

Safety & efficacy not established

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Adverse Effects

>10%

Mild to moderate inflammation (63%)

Mild to moderate burning (63%)

Mild to moderate erosion (44-48%)

Mild to moderate pain (44-48%)

Mild to moderate pruritus (44-48%)

Mild to moderate bleeding (22%)

1-10%

Stinging (7%)

Erythema (5%)

Severe inflammation (8-12%)

Severe burning (8-12%)

Severe erosion (8-12%)

Severe pain (8-12%)

Severe pruritus (8-12%)

Headache (6-9%)

Insomnia

Dizziness

Hematuria

Nausea

Vomiting (5%)

Severe bleeding (1%)

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Warnings

Contraindications

Hypersensitivity

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: not known whether topically applied podofilox is distributed into human milk; potential for serious adverse reactions in nursing infants

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Half-Life: 1-4.5 hr

Absorption: little systemic

Mechanism of Action

Antimitotic agent from plant families Coniferae and Berberidaceae

Interference with microtubular function of the keratinocytes contained in the warts and local vascular structures; local immunomodulating effects

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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