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cortisone (Rx)Brand and Other Names:

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 5mg
  • 10mg
  • 25mg
more...

Anti-inflammatory/Immunosuppressive

2.5-10 mg/kg/day PO divided q8hr or 25-300 mg/day PO qDay or divided q12hr

1-5 mg/kg IM qDay

Physiologic Replacement

0.5-0.75 mg/kg/day PO divided q8hr or 25-35 mg/day

0.25-0.35 mg/kg IM qDay

Other Indications & Uses

Adrenal insufficiency, conditions treated with immunosuppression, corticosteroid responsive dermatoses, inflammatory conditions

Dosage Forms & Strengths

tablet

  • 5mg
  • 10mg
  • 25mg
more...

Anti-inflammatory/Immunosuppressive

2.5 mg-10 mg/kg/day PO or 20-300 mg/sq.meter/day PO divided q6-8hr

Physiologic Replacement

0.5-0.75 mg/kg/day PO or 20-25 mg/sq.meter/day PO divided q8hr

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Interactions

Interaction Checker

cortisone and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 
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            Adverse Effects

            >10%

            Insomnia

            Indigestion

            Incr appetite

            1-10%

            Hirsutism

            Arthragia

            Cataract

            Epistaxis

            DM

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            Warnings

            Contraindications

            Systemic fungal infection

            Hypersensitivity to cortisone

            Cautions

            Short acting agent

            Cirrhosis, ocular herpes simplex, HTN, diverticulitis, hypothyroidism, myasthenia gravis, PUD, osteoporosis, ulcerative colitis, psychotic tendencies, untreated systemic infections, renal insufficiency, pregnancy

            Hydroxylated to active compound hydrocortisone

            When used to treat adrenocortical insufficiency may need to use additional mineralocorticoid

            Not indicated for IV use

            DM, thromboembolic disorders

            Long-term treatment: Risk of osteoporosis, myopathy, delayed wound healing

            Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated

            Latent TB may be reactivated

            Monitor patients with positive tuberculin test

            Some suggestion of slightly increase cleft palate risk if corticosteroids used in pregnancy, but not fully substantiated

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            Pregnancy & Lactation

            Pregnancy Category: not available

            Lactation: excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Glucocorticoid; elicits mild mineralocorticoid activity and moderate anti-inflammatory effects; controls or prevents inflammation by controling the rate of protein synthesis, suppressing migration of PMNs and fibroblasts, and reversing capillary permeability

            Absorption

            Duration: 10 days (IM); 30-36 hr (PO)

            Onset: PO: 24 hr (IM); within 2 hr (PO)

            Distribution

            Protein Bound: 90%

            Metabolism

            Extensively and rapidly in the liver to hydrocortisone (active metabolite) which is then metabolized in tissues and the liver to inactive glucuronide & sulfate metabolites

            Metabolites: Hydrocortisone (active), glucuronide and sulfate metabolites (inactive)

            Elimination

            Half-life: 0.4-2 hr

            Excretion: Mainly in urine, minimally in bile

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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