cosyntropin (Rx)Brand and Other Names:Cortrosyn, Synthetic ACTH

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

powder for injection

  • 0.25mg/vial
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Screening of Adrenocortical Insufficiency

0.25-0.75 mg direct IV/IM

May administer 0.25 mg as IV infusion at 40 mcg/hr over 6 hr to provide greater stimuluse to the adrenal gland

Dosage Forms & Strengths

powder for injection

  • 0.25mg/vial
more...

Screening of Adrenocortical Insufficiency

< 2 years

  • 0.125 mg IV/IM

> 2 years

  • 0.25-0.75 mg direct IV/IM
  • May administer 0.25 mg as IV infusion at 40 mcg/hr over 6 hr to provide greater stimuluse to the adrenal gland
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Interactions

Interaction Checker

cosyntropin and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Flushing

            Mild fever

            Pruritus

            Chronic pancreatitis

            Hypersensitivity

            Rash

            Peripheral edema

            Tachycardia

            Bradycardia

            Adrenal hemorrhage

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            Warnings

            Contraindications

            Hypersensitivity to cosyntropin

            Cautions

            Hx of hypersensitivity to natural ACTH

            Use caution in patients with gastrointestinal disease, cardiovascular disease, hepatic disease, infections, myasthenia gravis, ocular disease, psychiatric disturbances, osteoporosis, renal disease, thyroid disease

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Mimics natural ACTH; stimulates adrenal cortex to secrete adrenal steroids (cortisone and hydrocortisone), androgenic substances, and aldosterone

            Pharmacokinetics

            Duration: IM: <4 hr

            Onset: IM: 1 hr

            Time to peak plasma concentration: Within 1 hr (IM, IV push)

            Bioavailability: Well absorbed from parenteral route

            Vd: 43%

            Half-life: 7 min

            Metabolism: Unknown

            Excretion: Urine

            Absorption: Rapid (IM)

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            Administration

            IV Incompatibilities

            Compatibility of cosyntropin for injection with other drugs depends on several factors (eg, concentration of the drugs, specific diluents used, resulting pH, temperature)

            IV/IM Administration

            Administer by IM or IV injection or by IV infusion

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
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            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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