cyclopentolate/phenylephrine (Rx)

Brand and Other Names:Cyclomydril
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cyclopentolate/phenylephrine

ophthalmic solution

  • 0.2%/1%
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Mydriasis/Cycloplegia Diagnosis

1-2 gtt in the conjunctival sac q5-10 min, not to exceed 3 times

Dosage Forms & Strengths

cyclopentolate/phenylephrine

ophthalmic solution

  • 0.2%/1%
more...

Mydriasis/Cycloplegia Diagnosis

1-2 gtt in the conjunctival sac q5-10 min, not to exceed 3 times

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Interactions

Interaction Checker

and cyclopentolate/phenylephrine

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     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Blurred vision

            Burning sensation in eye

            Hypersensitivity reactions such as allergic conjunctivitis or dermatitis

            Sensitivity to light

            Headache or browache

            Reactive hyperemia

            Transient burning or stinging

            Transient keratitis

            Rare

            • Hypertension, tachycardia, palpitation, premature ventricular contractions, tachyarrhythmia, vasodilatation
            • Ataxia, confusion, occipital headache, psychotic disorder, raised intraocular pressure, seizure, trembling or tremors
            • Increased perspiration
            • Pallor or blanching
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            Warnings

            Contraindications

            Untreated narrow-angle glaucoma

            Hypersensitivity to any component

            Cautions

            Reduce dose if used within 21 d of MAO inhibitors or TCAs

            Wait 5 minutes between multiple drops (no >3 drops needed)

            May cause false-normal tonometry readings, tonometry should be performed before phenylephrine is administered

            Restrict to short term use (safety and efficacy of long-term use not established)

            Use caution in Down syndrome (predisposed to angle-closure glaucoma)

            Remove contact lenses prior to administration and wait 15 min before reinserting

            The eldrely may be predisposed to increased intraocular pressure

            May result in psychotic reactions and behavioral disturbances in children 30-45 min following instillation

            Minimize absorption by using 1 drop of solution per eye and applying presure

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Unknown if excreted in breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Cyclopentolate blocks the action of acetylcholine resulting in relaxation of the cholinergically innervated sphincter muscle of the iris

            Cholinergic stimulation of the accommodative ciliary muscle of the lens is also blocked

            Anticholinergic effects of cyclopentolate in the eye produce dilation of the pupil (mydriasis) and paralysis of accommodation (cycloplegia)

            Phenylephrine acts directly on alpha-adrenergic receptors in eye producing contraction of dilator muscle of pupil & constriction of arterioles in conjunctiva

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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