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cytomegalovirus immune globulin (CMV IG) (Rx)Brand and Other Names:CytoGam, cmv ig

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 50±10mg/mL (20mL, 50mL)
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Cytomegalovirus Prophylaxis

Monitor vital signs preinfusion, during infusion & postinfusion, renal function

Kidney Transplant

  • 150 mg/kg IV infusion within 72 hours of transplant, THEN 100 mg/kg 2, 4, 6, 8 weeks posttransplant, THEN 50 mg/kg 12 & 16 weeks posttransplant 

Liver, Pancreas, Heart, Lung Transplant

  • 150 mg/kg IV infusion within 72 hours of transplant & 2, 4, 6, 8 weeks posttransplant, THEN 100 mg/kg 12 & 16 weeks posttransplant

CMV Pneumonia (Orphan)

For use in conjunction with ganciclovir sodium for the treatment of cytomegalovirus pneumonia in bone marrow transplant patients

Orphan indication sponsor

  • Bayer Corporation, Pharmaceutical Division, Biological Products; 400 Morgan Lane; New Haven, CT 06516

Dosage Forms & Strengths

injectable solution

  • 50±10mg/mL (20mL, 50mL)
more...

Congenital CMV (Orphan)

Prevention of congenital cytomegalovirus (CMV) infection following primary CMV infection in pregnant women

Orphan indication sponsor

  • Biotest Pharmaceuticals Corporation; 5800 Park of Commerce Blvd, NW; Boca Raton, FL 33487
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Interactions

Interaction Checker

cytomegalovirus immune globulin (CMV IG) and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
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            Adverse Effects

            1-10%

            Diaphoresis

            Flushing, Facial

            Fever

            Shivering

            Nausea, Vomiting

            Arthralgia

            Backache

            Muscle cramps

            Wheezing

            <1%

            Anaphylaxis (rare)

            Aseptic meningitis (Rare)

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            Warnings

            Contraindications

            History of severe rxn to immune globulins

            Cautions

            Made from human donors, so theoretical risk of pathogen transmission

            Contains sucrose as stabilizer, associated with higher risk of IV immune globulin-related renal dysfunction

            Possibility of other adverse rxns associated with IV immune globulins, eg, aseptic meningitis synd, transfusion-related acute lung injury

            Renal impairment

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            IgG antibodies to CMV pooled from human donors

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            Administration

            IV Administration

            Does not contain preservatives so begin infusion within 6 hr of entering into vial & complete within 12 hr

            Do not dilute

            Do not shake vial: avoid foaming

            Do not use if discoloration/particulate matter/turbidity

            Administer thru IV line with in-line filter (15 micron) & infusion pump. Separate IV line preferred but may be given IVPB into preexisting line with NS or D20W, D10W, D5W & D2.5W with or without NaCl. If preexisiting line must be used, do not dilute CytoGam more than 1:2

            Administer initial dose at 15 mg/kg/hr, after 30 min incr to 30 mg/kg/hr x 30 min, then to 60 mg/kg/hr provided no adverse rxns occur at either step. NMT 75 mL/hr Subsequent doses start 15 mg/kg/hr x15 min, then 30 mg/kg/hr x15 min, then 60 mg/kg/hr provided no adverse rxns; NMT 75 mL/hr

            Adverse rxns may require slowing/interrupting infusion

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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