potassium citrate/citric acid (Rx)

Brand and Other Names:Cytra-K
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

potassium citrate/citric acid

oral solution

  • (1100mg/334mg)/5mL
  • Each 2 mL contains 2 mEq potassium ion and is equivalent to 2 mEq bicarbonate (HCO3)
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Urinary Alkalinization

Indicated for long-term maintenance of an alkaline urine (eg, patients with uric acid and cystine calculi of the urinary tract), especially when the administration of sodium salts is undesirable or contraindicated

Usual dose: 15-30 mL PO diluted with 1 glass of water QID (after meals and at bedtime)

Administration

Dilute oral solution in water according to directions, followed by additional water, if desired

Proper dilution may help prevent gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations

Palatability enhanced if chilled

Dosage Forms & Strengths

potassium citrate/citric acid

oral solution

  • (1100mg/334mg)/5mL
  • Each 2 mL contains 2 mEq potassium ion and is equivalent to 2 mEq bicarbonate (HCO3)
more...

Urinary Alkalinization

Indicated for long-term maintenance of an alkaline urine (eg, patients with uric acid and cystine calculi of the urinary tract), especially when the administration of sodium salts is undesirable or contraindicated

Usual dose: 5-15 mL PO diluted with one-half glass of water QID (after meals and at bedtime)

Administration

Dilute oral solution in water according to directions, followed by additional water, if desired

Proper dilution may help prevent gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations

Palatability enhanced if chilled

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Interactions

Interaction Checker

and potassium citrate/citric acid

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    Contraindicated

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            Adverse Effects

            Frequency Not Defined

            Hyperkalemia

            Alkalosis

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            Warnings

            Contraindications

            Severe renal impairment with oliguria or azotemia

            Untreated Addison's disease

            Adynamia episodica hereditaria

            Acute dehydration

            Heat cramps

            Anuria

            Severe myocardial damage

            Hyperkalemia from any cause

            Hypersensitivity to any ingredient

            Cautions

            Small bowel lesions (eg, stenosis with or without ulceration) reported with potassium salts (mostly from enteric-coated products)

            Large doses may cause hyperkalemia and alkalosis, especially in presence of renal disease

            Caution with low urinary output

            Direct patients to dilute solution with water before ingestion to minimize GI injury associated with concentrated potassium preparations

            Take after meals to avoid saline laxative effect

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Unknown whether distributed in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Potassium citrate is absorbed and metabolized to potassium bicarbonate and this acts as a systemic alkalizer

            Elimination

            Excretion: Oxidation of potassium citrate is virtually complete so <5% is excreted in the urine unchanged

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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