Dosing & Uses
Dosage Forms & Strengths
600 mg/day divided BID/TID PO
1 hour before or 2 hours after meals
Other Indications & Uses
Rickettsial fevers (Rocky mountain spotten fever, typhus, Q fever), various infections caused by Mycoplasma pneumoniae, Chlamydia trachomatis, Chlamydia psittacci, Ureaplasma. urealyticum, Borrelia recurrentis, Haemophilus ducreyi, Yersinia pestis, Francisella tularensis, Vibrio cholerae, Campylobacter fetus, Brucella sp., Bartonella bacilliformis, E. coli, Enterobacter aerogenes, Acinetobacter sp., H. influenzae, Shigella sp., Klebsiella sp., Sterptococcus pneumoniae, skin infections caused by Staphylococcus aureus (not the drug of choice)
When penicillin is contraindicated: N. gonorrheae (infections in women), Treponema pallidum, Lsiteria monocytogenes, Bacillus anthracis, Fusobacteriunm fusiforme, Actinomyces israelii, Clostridium sp.
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Photosensitivity rxn (more frequent & severe than other tetracyclines), reversible
Dose-related diabetes insipidus (does not occur with other tetracyclines)
Discoloration of teeth
Photosensitivity may occur with prolonged exposure to sunlight or tanning equipment
Reduce dose in renal impairment
Consider drug serum level determinations in prolonged therapy
Tetracycline use during tooth development (last one-half of pregnancy through age 8 y) can cause permanent discoloration of teeth
Fanconilike syndrome may occur with outdated tetracyclines
Pregnancy & Lactation
Pregnancy Category: D
Lactation: enters breast milk/not recommended by manufacturer
Tetracyclines bind to calcium. The amount of demeclocycline absorbed by the infant is significantly decreased by the calcium in breast milk.
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Absorption: 60-80% in fasting adults, reduced by 50% or more by food or milk
Peak Plasma: (150 mg x1): 0.9-1.2 mcg/mL; (300 mg x1) 1.5-1.7 mcg/mL
Half-Life: 11-17 hr; severe renal impairment: 42-68 hr
Mechanism of Action
Inhibits bacterial protein synthesis by binding with 30S and possibly 50S ribosomal subunit(s).
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.