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metyrosine (Rx)Brand and Other Names:Demser

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 250mg
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Chronic Pheochromocytoma

Indicated for treatment of patients with pheochromocytoma for: 1) preoperative preparation for surgery; 2) management when surgery is contraindicated; and 3) chronic treatment with malignant pheochromocytoma

Initial: 250 mg PO q6hr; may increase by 250-500 mg/day, not to exceed 4 g/day

Maintenance: Typically 2-3 g/day divided q6hr

Dosing Considerations

Not indicated for essential hypertension

When used for preoperative preparation, the optimally effective dose should be given for at least 5-7 days

Psychosis (Orphan)

Treatment of velocardiofacial syndrome associated psychosis

Orphan indication sponsor

  • Aton Pharma, Inc; 3150 Brunswick Place; Lawrenceville, NJ 08648

Dosage Forms & Strengths

capsule

  • 250mg
more...

Chronic Pheochromocytoma

Indicated for treatment of patients with pheochromocytoma for: 1) preoperative preparation for surgery; 2) management when surgery is contraindicated; and 3) chronic treatment with malignant pheochromocytoma

<12 years: Safety and efficacy not established

≥12 years

  • Initial: 250 mg PO q6hr; may increase by 250-500 mg/day, not to exceed 4 g/day
  • Maintenance: Typically 2-3 g/day divided q6hr

Dosing Considerations

Not indicated for essential hypertension

When used for preoperative preparation, the optimally effective dose should be given for at least 5-7 days

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Interactions

Interaction Checker

metyrosine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Sedation (>20%)

            1-10%

            Diarrhea (10%)

            Exrapyramidal Symptoms (10%)

            Frequency Not Defined

            Fatigue

            Headache

            Psychic Disturbances

            Galactorrhea

            Sexual dysfunction

            Nausea

            Vomiting

            Xerostomia

            Nasal stuffiness

            Dysuria

            Crystalluria

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            Warnings

            Contraindications

            Hypersensitivity to metyrosine

            Cautions

            Additive sedative effects w/ alcohol and other CNS depressants

            Take enough fluid to prevent crystalluria

            Use caution in hepatic or renal impairment

            Not recommended for essential HTN

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known if excreted into breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Inhibits synthesis of endogenous catecholamines by inhibiting tyrosine hydroxylase

            Pharmacokinetics

            Half-Life: 3-4 hr

            Bioavailability: Well absorbed

            Metabolism: liver

            Metabolite: Catechol metabolites (inactive)

            Excretion: urine 53-88%

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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