dextrose (Antidote) (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

IV solution

  • D50W
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Acute Alcohol Intoxication

25-50 g (50-100 mL of D50W solution); administer with thiamine (50-100 mg IV) to prevent Wernicke's encephalitis

Sulfonylurea Overdose

10-25 g (40-100 mL of D25W solution or 20-50 mL of D50W solution) IV; may require repeated boluses

Insulin Overdose

400-600 mg of glucose/kg/hr needed for most insulin overdoses

Alternatively, administer 25-50 g (D50W) IV; may repeat doses in severe cases; determine glucose levels before injecting dose; in emergencies, may administer promptly before obtaining glucose results

Hyperkalemia

25-50 g (250-500 mL D10W) plus 10 units regular insulin IV over 30-60 min

Dosage Forms & Strengths

IV solution

  • D50W
more...

Insulin Induced Hypoglycemia

< 6 months: 250-500 mg/kg/dose (1-2 mL/kg/dose D25W) 

> 6 months: 0.5-1g/kg/dose (2-4 mL/kg/dose D25W)

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Interactions

Interaction Checker

and dextrose (Antidote)

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    Contraindicated

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            Adverse Effects

            Frequency Not Defined

            Possibility of intracellular lactic acid production in setting of ischemic brain cells & hyperglycemia

            Hypokalemia

            Edema

            Hyper/hypovolemia

            Dehydration

            Fever

            Mental cofusion

            Unconsciousness

            Ketonuria

            Glycosuria

            Polyuria

            Phlebitis

            Venous thrombosis

            Metabolic acidosis

            Diarrhea

            Polydipsia

            Vein irritation

            Pulmonary edema/tachypnea

            Extravasation can result in tissue damage

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            Pharmacology

            Mechanism of Action

            Source of calories and fluid for patients unable to obtain adequate oral intake

            Substrate for ATP production for aerobic metabolism; promotes glycogen deposition in the liver

            In hyperkalemia dextrose in combination with insulin stimulates the uptake of potassium by cells (especially in muscle tissue), which in turn lowers serum potassium

            Pharmacokinetics

            Onset of action: 10 min (PO; treatement of hypoglycemia)

            Absorption: Rapid from the small intestine

            Metabolism: Metabolized to carbon dioxide and water

            Time to peak: 40 min (PO)

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
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            • Compare formulary status to other drugs in the same class.
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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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