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phenoxybenzamine (Rx)Brand and Other Names:Dibenzyline

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 10mg
more...

Hypertension Pheochromocytoma

10 mg PO BID initially; increase qOD to 20-40 mg PO BID/TID (sometimes higher doses necessary)

Bladder Management (Off-label)

Initial 10 mg PO qD; can be increased q5d by 10 mg PO q8-12hr

Other Indications & Uses

Off-label: Raynaud's phenomenon, overactive bladder (neurogenic, prostatic obstruction), shock, hypertensive emergencies d/t epinephrine

Dosage Forms & Strengths

capsule

  • 10mg
more...

Pheochromocytoma Hypertension (Off-label)

0.25-1 mg/kg PO qD; increase to effect slowly; not to exceed 10 mg/day 

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Interactions

Interaction Checker

phenoxybenzamine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Orthostatic hypotension

            Tachycardia

            Dizziness

            Drowsiness

            Fatigue

            Malaise

            Sedation

            Dry mouth

            Nausea

            Vomiting

            Inhibition of ejaculation

            Miosis

            Nasal congestion

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            Warnings

            Contraindications

            Hypersensitivity to phenoxybenzamine

            Any conditions in which fall in BP is undesirable

            Orthostatic hypotension

            Cautions

            Cerebral or coronary arteriosclerosis, CHF, respiratory infection, renal impairment

            Concomitant use of drugs that stimulate alpha/beta receptors (may incr hypotension/tachycardia)

            May have carcinogenic potential

            First dose effect may occur, causing a sudden and drastic fall in blood pressure after administering the first dose.

            Hypotension/syncope may occur with first few doses or with increase in dose

            Minimize by using small first dose at bedtime

            Increase dose slowly

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Not known if excreted into breast milk, discontinue drug or do not nurse

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Half-Life: 24 hr

            Onset: several hours

            Duration: several days

            Bioavailability: 20-30%

            Metabolism: extensively metabolized in liver

            Metabolite: N-phenoxyisopropyl-benzylamine

            Excretion: urine & feces

            Mechanism of Action

            Alpha blocker, noncompetitive alpha-adrenergic blockade of post ganglionic synapses in smooth muscle, exocrine glands

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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