Dosing & Uses
Dosage Forms & Strengths
Indicated for Staphylococcus aureus infections
125-500 mg PO q6hr
Take on empty stomach
Not studied; total dosage reduction should be considered
Serious - Use Alternative
Significant - Monitor Closely
Seizures with extremely high doses &/or renal failure
Rash (maculopapular to exfoliative)
Hypersensitivity to penicillins, cephalosporins, imipenem
Initial treatment of severe infections
Concomitant live bacterial vaccines
Monitor PT if patient is taking warfarin concurrently
Prolonged use may result in superinfection
Elimination of drug in neonates is slow; use caution
Pregnancy & Lactation
Pregnancy Category: B
Lactation: excreted in breast milk, use caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Binds to one or more penicillin binding proteins, which in turn inhibit synthesis of bacterial cell wall synthesis. For treatment of infections caused by penicillinase-producing staphylococci.
Resistance to this drug results from alterations in penicillin-binding proteins.
Half-Life: 0.6-0.8 hr
Peak Plasma Time: 0.5-2 hr
Protein Bound: 96%
Absorption: 35-76%, decreased by food
Distribution: widespread, highest in kidneys & liver, CSF low
Metabolism: hepatic CYP3A4
Excretion: Urine (56%), feces
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.