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benzphetamine (Rx)Brand and Other Names:Didrex, Regimex

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet: Schedule III

  • 25mg (Regimex)
  • 50mg (Didrex)
more...

Obesity

Indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of ≥30 kg/m² who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone

25-50 mg PO qDay initially; may increase dose or frequency according to response up to TID

Dosage Forms & Strengths

tablet: Schedule III

  • 25mg (Regimex)
  • 50mg (Didrex)
more...

Obesity

Indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of ≥30 kg/m² who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone

<12 years: Safety and efficacy not established

≥12 years: 25-50 mg PO qDay initially; may increase dose or frequency according to response up to TID

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Interactions

Interaction Checker

benzphetamine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abdominal pain

            Blood pressure incr

            Constipation

            Diarrhea

            Dizziness

            Dry mouth

            Headache

            Insomnia

            Ischemic cardiac events associated with chronic amphetamine use

            Libido changes

            Nausea

            Palpitations

            Psychotic episodes (rare)

            Restlessness

            Tachycardia

            Tremor

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            Warnings

            Contraindications

            Advanced arteriosclerosis

            Symptomatic cardiovascular disease including arrhythmias

            Hyperthyroidism

            Moderate to severe hypertension

            Hypersensitivity to sympathomimetic amines

            Glaucoma

            Agitated state

            History of drug abuse

            Pregnancy/lactation; women planning to get pregnant

            Use within 14 days of MAOIs

            Do not use in combination with other anorectic agents including prescription, OTC, or herbal

            Use of anorectic agents associated with increased risk of developing pulmonary hypertension (PH) (rare, but often fatal disorder); use >3 months associated with 23-fold increased risk of developing PH (benzphetamine not specifically studied)

            Immediately discontinue if onset or aggravation of exertional dyspnea, or unexplained symptoms of angina pectoris, syncope, or lower extremity edema emerge suggesting possible PH

            Valvular heart disease associated with use of some anorectics (no cases reported with benzphetamine monotherapy)

            Not recommended for patients who used any anorectic agents within prior year

            Cautions

            Discontinue when tolerance develops - DO NOT EXCEED recommended dose

            Diabetics: insulin requirements may be altered

            Mild hypertension

            May impair ability to drive &/or operate heavy machinery

            Alkaline urine will increase half-life

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            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: enters breast milk/not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Amphetamine anorexigenic agent

            Pharmacokinetics

            Metabolism: by cytochrome P450 enzymes

            Excretion: 5-30% unchanged in urine, highly dependent on pH

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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