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diethylpropion (Rx)Brand and Other Names:

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet: Schedule IV

  • 25mg

tablet, controlled-release: Schedule IV

  • 75mg
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Obesity

Immediate-release

  • 25 mg PO q8hr 1 hour AC
  • May add 1 additional 25 mg dose PO midevening to overcome night hunger

Controlled-release

  • 75 mg PO qDay, swallowed whole, in midmorning

Obesity

<16 years

  • Safety & efficacy not established

> 16 years

  • Immediate release: 25 mg PO q8hr AC
  • Controlled release: 75 mg PO qDay, swallowed whole, in midmorning
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Interactions

Interaction Checker

diethylpropion and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Increased blood pressure

            Palpitations

            Rash

            Urticaria

            Constipation

            Nausea

            Stomach cramps

            Vomiting

            Xerostomia

            Central nervous system stimulation

            Dizziness

            Headache

            Insomnia

            Pain

            Blurred vision

            Mydriasis

            Restlessness

            Menstrual irregularity

            Impotence, changes in libido

            <1%

            Cardiac dysrhythmia

            Cardiomyopathy

            Agranulocytosis

            Leukopenia

            Cerebral ischemia

            Cerebrovascular accident

            Psychotic disorder (rare)

            Primary pulmonary hypertension

            Drug dependence (rare)

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            Warnings

            Contraindications

            Advanced arteriosclerosis

            Hyperthyroidism

            Severe HTN

            Hypersensitivity to sympathomimetic amines

            Glaucoma

            Agitated state

            History of drug abuse

            Pregnancy (especially first trimester)

            Within 14 days of MAOI

            Prolonged use not indicated

            Concurrent use with other anorectic agents

            Cautions

            Discontinue when tolerance develops - DO NOT EXCEED recommended dose

            Pregnancy, lactation

            Epilepsy

            Use caution in patients with diabetes mellitus or Tourette's syndrome

            Incidence of primary pulmonary hypertension has been associated with therapy use

            Mild hypertension, symptomatic cardiovascular disease

            Development of valvular heart disease reported

            May impair ability to drive &/or operate heavy machinery

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: Excreted in breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Amphetamine-related anorexigenic agent; action in reducing apetite may be secondary to CNS effects that may involve stimulation of hypothalamus to release norepinephrine

            Pharmacokinetics

            Metabolism: Undergoes reduction and N-dealkylation to form active metabolites

            Duration: 4 hr

            Half-life elimination: 4-6 hr (aminoketone metabolites)

            Excretion: primarily urine (>75%)

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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