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betamethasone topical (Rx)Brand and Other Names:Diprolene, Luxiq, more...Dermabet, Alphatrex, Diprolene AF, Diprolene Glycol, Diprosone, Valnac, BetaVal, Sernivo

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream/lotion/ointment

  • 0.05%
  • 0.1%

gel

  • 0.05%

foam

  • 0.12% (Luxiq)

spray

  • 0.05% (Sernivo)
more...

Plaque Psoriasis

Indicated for mild-to-moderate plaque psoriasis in adults

Sernivo spray: Apply to affected area(s) q12hr

Steroid-Responsive Dermatoses

Apply ointment/cream/lotion/gel (betamethasone dipropionate) qDay or q12hr

Apply ointment (betamethasone valerate) qDay or q8hr

Luxiq: Apply foam to scalp q12hr

Dosage Forms & Strengths

cream/lotion/ointment

  • 0.05%
  • 0.1%

gel

  • 0.05%

foam

  • 0.12%
more...

Inflammatory Conditions

<12 years: Not recommended

≥12 years: Apply to affected area q12hr (low or medium potency)

Dosing considerations

  • Use minimal amount for shortest period of time to avoid HPA axis suppression

Steroid-Responsive Dermatoses

Apply ointment/cream/lotion/gel (betamethasone dipropionate) qDay or q12hr

Apply ointment (betamethasone valerate) qDay or q8hr

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Adverse Effects

Frequency Not Defined

Skin atrophy

Striae

Allergic dermatitis

Burning

Dry skin

Erythema folliculitis

Hypertrichosis

Irritation

Miliaria

Vesiculation

Acneform lesions

Pigmentation changes

HPA suppression (with higher potency used >2 wk)

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Warnings

Contraindications

Underlying infection present

Hypersensitivity

Ophthalmic use

Cautions

Chronic topical corticosteroid therapy may interfere with growth and development in children

Prolonged treatment with corticosteroids is associated with Kaposi sarcoma (consider discontinuation of therapy if diagnosed)

Discontinue if contact dermatitis occurs; not for use in patients with decreased skin circulation

Manifestations of Cushing syndrome, hyperglycemia, or glycosuria occur, especially if occlusive dressings are used

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Pregnancy & Lactation

Pregnancy category: C

Lactation: It is not known whether topical corticosteroid use could result in sufficient systemic absorption to produce detectable quantities in human milk; use with caution.

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Mechanism of Action

Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes, inhibiting macrophage accumulation in inflamed areas, reducing leukocyte adhesion to capillary endothelium, reducing capillary wall permeability and edema formation, decreasing complement components, antagonizing histamine activity and release of kinin from substrates, and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation

Absorption

Yes

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Administration

Topical Administration

Use medium to very high potency for less than 2 weeks to reduce local and systemic side effects

Use low potency for chronic therapy

Avoid medium to very high potency on face, folds, and groin, because use in these areas can increase steroid absorption

Use lower potency for children (ie, increased BSA/kg, therefore increased systemic absorption)

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Images

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Formulary

FormularyPatient Discounts

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
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  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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