Brand and Other Names:Antabuse
- Classes: Psychiatry Agents, Other
Dosing & Uses
Dosage Forms & Strengths
Only administer after the patient has abstained from ethanol for at least 12 hr
Use ONLY as adjunct to supportive & psychotherapeutic treatment; in motivated patient
500 mg PO qDay initially for 1-2 weeks; not to exceed 500 mg/day
Maintenance: 250 mg PO qDay (125-500 mg range); continue therapy until a bases for self-control has been established; patient may continue to take drug therapy for months or even years
Glioblastoma Multiforme (Orphan)
Combination of disulfiram and copper gluconate
Orphan designation for treatment of glioblastoma multiforme
- Cantex Pharmaceuticals, Inc; 1792 Bell Tower Lane; Weston, Florida 33326
Safety and efficacy not established
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Black Box Warnings
Never administer to a patient in a state of alcohol intoxication or without patient's full knowledge
Instruct patient's relatives accordingly
Ethanol, metronidazole, paraldehyde, any alcohol-containing products (e.g., some mouthwashes)
Severe cardiac disease
When EtOH ingested by patient taking disulfiram: flushing, throbbing HA, N/V, diaphoresis, thirst, SOB, syncope, vertigo, blurred vision, confusion; respiratory depression, cardiac arrhythmias, MI or liver failure may occur
Use caution in diabetes, hypothyroidism, seizures, nephritis, hepatic impairment
Severe hepatitis and/or hepatic failure has been associated with therapy even in patients without prior history of abnormal hepatic function
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown/not recommended
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Produces sensitivity to EtOH via blocking its oxidation at acetaldehyde stage, resulting in unpleasant reactions including palpitations, hypotension, chest pain, nausea, vertigo, thirst, flushing, and nausea
Peak plasma time: 4 hr
Peak plasma concentration: 2.4 mcg/mL
Duration: up to 2 wk
Onset: 2-12 hr
Enzymes inhibited: hepatic CYP2C9, CYP2E1
Excretion: Feces and exhaled gases
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
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