Brand and Other Names:Dovonex, Calcitrene Ointment, more...Sorilux
- Classes: Antipsoriatics, Topical
Dosing & Uses
Dosage Forms & Strengths
Moderate Plaque Psoriasis
- Apply thin layer to affected skin BID
- Apply to affected scalp BID
- Apply thin layer topically to affected skin BID
Rub in gently and completely
May use for up to 8 weeks
Foam is flammable, contents under pressure, do not expose to heat or store at temperatures above 120 degrees F
Safety and efficacy not established
Serious - Use Alternative
Significant - Monitor Closely
Worsening of psoriasis including facial/scalp
Contact dermatitis, including allergic contact dermatitis
Hypersensitivity, use on face, hypercalcemia, or evidence Vit D toxicity
Photosensitivity reported; avoid excessive exposure to natural or artificial sunlight
Contact dermatitis, including allergic contact dermatitis, reported
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Absorption: 5-6% systemically
Metabolism: converted to inactive metabolites within 24 hr
Mechanism of Action
In vitro evidence suggests drug is roughly equipotent to natural vitamin D in its effects on proliferation & differentiation of various cell types
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