doxylamine (OTC)

Brand and Other Names:Unisom
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 25mg
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Insomnia

25 mg PO qHS PRN 30 min before bedtime

Upper Respiratory Tract Allergy

50 mg PO q4-6hr

Insomnia

<12 years: Not recommended

>12 years: 25 mg PO qHS PRN 30 min before bedtime

Avoid use in elderly because of high incidence of anticholinergic effects

Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity

May exacerbate existing lower urinary conditions or benign prostatic hyperplasia

Tolerance develops when used as hypnotic

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Interactions

Interaction Checker

and doxylamine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Minor anticholinergic effects

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            May cause CNS depression, which may impair physical and mental activities

            Not to exceed 2 weeks of use

            Caution in asthma, glaucoma, enlarged prostate, cardiovascular disease, respiratory disease, or thyroid dysfunction

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: excretion in milk unknown

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Competes for H1-receptor sites on target cells; has anticholinergic effects, which depresses labyrinthine function, blocks chemoreceptor trigger zone, and diminishes vestibular stimulation

            Absorption

            Peak Plasma Time: 2-3 hr

            Peak Plasma Concentration: 100 ng/mL

            Elimination

            Half-Life: 10-12 hr

            Excretion: Urine

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