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vitamin D (Rx, OTC)Brand and Other Names:Drisdol, Calciferol, more...cholecalciferol, 1,25-Dihydroxycholecalciferol, ergocalciferol

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

1 mcg = 40 international units (IU)

oral solution

  • 8000IU/mL (200mcg/mL)

capsule

  • 50,000IU (1.25mg)

tablet

  • 400IU (10mcg)
  • 2000IU (50mcg)
more...

Nutritional Supplementation

Recommended daily allowance (RDA)

19-70 years: 600 IU (15 mcg)/day

Pregnant or lactating women: 600 IU (15 mcg)/day

Osteoporosis

Prophylaxis and treatment

>50 years: 800-1000 IU (20-25 mcg) PO once daily with calcium supplements

Hypoparathyroidism

50,000-200,000 IU (0.625-5 mg) PO once daily with calcium supplements

Vitamin D-Resistant Rickets

12,000-500,000 IU (0.3-12.5 mg) PO once daily

Familial Hypophosphatemia

10,000-60,000 IU (0.25-1.5 mg) PO once daily with phosphate supplements

Dosage Forms & Strengths

1 mcg = 40 IU

oral solution

  • 8000IU/mL (200mcg/mL)

capsule

  • 50,000IU (1.25mg)

tablet

  • 400IU (10mcg)
  • 2000IU (50mcg)
more...

Nutritional Supplementation

RDA

0-12 months: 400 IU (10 mcg) PO once daily

1-18 years: 600 IU (15 mcg) PO once daily

Vitamin D-Resistant Rickets

12,000-500,000 IU (0.3-12.5 mg) PO once daily

Familial Hypophosphatemia

40,000-80,000 IU (1-2 mg) PO once daily with phosphate supplements; may be reduced after stage of growth is complete

Nutritional Supplementation

RDA

<70 years: 600 IU (15 mcg) PO once daily

>70 years: 800 IU (20 mcg) PO once daily

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Interactions

Interaction Checker

vitamin D and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Arrhythmias

            Confusion

            Constipation

            Dry mouth

            Headache

            Hypercalcemia

            Lethargy

            Metallic taste

            Muscle or bone pain

            Nausea

            Sluggishness

            Vomiting

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            Warnings

            Contraindications

            Hypercalcemia

            Hypervitaminosis D

            Ergocalciferol (oral): Gastrointestinal (GI), liver, or biliary disease associated with malabsorption of vitamin D analogues

            Documented hypersensitivity with drugs that could have allergenic crossreactivity with ergocalceferol

            Cautions

            Ergocalciferol: Use with caution in renal impairment (strong caution), heart disease, kidney stones, arteriosclerosis

            Obtain serum calcium twice weekly during titration

            Discontinue if patient becomes hypercalcemic

            Presence of tartrazine in some products may cause allergic reactions

            Vitamin D toxicity may last ≥2 months after therapy is discontinued

            Restrict intake in infants with idiopathic hypercalcemia

            Concurrent use of cardiac glycosides

            Adequate clinical response to vitamin D therapy is dependent on adequate dietary calcium

            Maintain normal serum phosphorous concentrations in patients treated for hyperphosphatemia to prevent metastatic calcification

            When treating hypoparathyroidism, concomitant treatment with intravenous calcium, parathyroid hormone, and/or dihydrotachysterol may also be required

            Adults with a body mass index (BMI) greater than 30 kg/m² are at high risk for vitamin D deficiency due to storage of vitamin D in adipose tissue; doses higher than recommended daily allowance may be required, but must be carefully monitored to avoid toxicity

            Metabolism of vitamin D may be altered in patients with chronic kidney disease

            In renal impairment, supplementation with ergocalciferol may be necessary; monitor closely

            In patients with rickets, the range between therapeutic and toxic doses is narrow in vitamin D–resistant patients; adjust dose based on clinical response to avoid toxicity

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            Pregnancy & Lactation

            Pregnancy category: C (ergocalciferol)

            Lactation: Drug is distributed into breast milk; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Stimulates calcium and phosphate absorption from small intestine; stimulates phosphate resorption at renal tubule; stimulates secretion of calcium into blood from bone

            Absorption

            Peak effect: 1 month with daily dosing

            Metabolism

            Metabolized in liver

            Elimination

            Excretion: Urine

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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